Extrathoracic Angio-Follicular Lymphoid Hyperplasia -Report of a Case with Emphasis on Interfollicular Fibrous Septation-

Abstract

Angiofollicular lymphoid hyperplasia is a very curious pathologic entity and has received diverse nomenclatures since its first description by Castleman') (1954) ; lymph node hyperplasia'), giant hemolymph node6) , lymph nodal hamartoma') , giant intrathoracic lymph nodesl ' ) , follicular lymphoreticulomaU ) , angiofollicular lymphoid hyperplasia7) , angiomatous lymphoid hamartoma13) , giant lymph node hyperplasia') , and isolated lymphoid tumor') Castleman3 ) (1956) originally reported that it is a localized mediastinal tumor and also presented the evidence that the condition is neither neoplastic nor thymic in origin, but rather a form of chronic nonspecific inflammation. Since then, cases of occurrence in extrathoracic sites were documented , 5, 8, 10, 13, H) and Abell') (1957) and Lattes'O) (1962) suggested lymphoid harmartomatous nature as to its histogenesis. But till now, no exact nature is kl1own, except its benign course validated by no recurrence of the tumor in any of the follow-up cases after excision, and by absence of features diagnostic for malignant lymphoma histopathologically. With a review of all lympho-reticular neoplasm and its allied conditions, we are aware of some difference in incidence among Koreans, and such speculations may extend to the benign non-neoplastic growth including al1giofollicular lymphoid hyperplasia. In the aspect of that 110 single proven document on this growth was found in Korean literature, the authors present a case of extrathoracic origin who received unnecessary radical operative procedure by fundamental lack of clinicans understanding on this disorder, and showed peculiar histological characteristics in addition to the findings summarized by Lattes et al'°) (1962).