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Human dopamine receptor nanovesicles for gate-potential modulators in high-performance field-effect transistor biosensors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Seon Joo | - |
dc.contributor.author | Song, Hyun Seok | - |
dc.contributor.author | Kwon, Oh Seok | - |
dc.contributor.author | Chung, Ji Hyun | - |
dc.contributor.author | Lee, Seung Hwan | - |
dc.contributor.author | An, Ji Hyun | - |
dc.contributor.author | Ahn, Sae Ryun | - |
dc.contributor.author | Lee, Ji Eun | - |
dc.contributor.author | Yoon, Hyeonseok | - |
dc.contributor.author | Park, Tai Hyun | - |
dc.contributor.author | Jang, Jyongsik | - |
dc.creator | 박태현 | - |
dc.date.accessioned | 2014-07-24T02:44:22Z | - |
dc.date.available | 2014-07-24T02:44:22Z | - |
dc.date.issued | 2014-07 | - |
dc.identifier.citation | Scientific Reports, Vol.4 No.4342, pp. 1-8 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10371/92614 | - |
dc.description.abstract | The development of molecular detection that allows rapid responses with high sensitivity and selectivity remains challenging. Herein, we demonstrate the strategy of novel bio-nanotechnology to successfully fabricate high-performance dopamine (DA) biosensor using DA Receptor-containing uniform-particle-shaped Nanovesicles-immobilized Carboxylated poly(3,4-ethylenedioxythiophene) (CPEDOT) NTs (DRNCNs). DA molecules are commonly associated with serious diseases, such as Parkinson's and Alzheimer's diseases. For the first time, nanovesicles containing a human DA receptor D1 (hDRD1) were successfully constructed from HEK-293 cells, stably expressing hDRD1. The nanovesicles containing hDRD1 as gate-potential modulator on the conducting polymer (CP) nanomaterial transistors provided high-performance responses to DA molecule owing to their uniform, monodispersive morphologies and outstanding discrimination ability. Specifically, the DRNCNs were integrated into a liquid-ion gated field-effect transistor (FET) system via immobilization and attachment processes, leading to high sensitivity and excellent selectivity toward DA in liquid state. Unprecedentedly, the minimum detectable level (MDL) from the field-induced DA responses was as low as 10 pM in real-time, which is 10 times more sensitive than that of previously reported CP based-DA biosensors. Moreover, the FET-type DRNCN biosensor had a rapid response time (< 1 s) and showed excellent selectivity in human serum. | en |
dc.language.iso | en | en |
dc.publisher | Nature Publishing Group | en |
dc.subject | 자연과학 | en |
dc.title | Human dopamine receptor nanovesicles for gate-potential modulators in high-performance field-effect transistor biosensors | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 박선주 | - |
dc.contributor.AlternativeAuthor | 송현석 | - |
dc.contributor.AlternativeAuthor | 권오석 | - |
dc.contributor.AlternativeAuthor | 정지현 | - |
dc.contributor.AlternativeAuthor | 이승환 | - |
dc.contributor.AlternativeAuthor | 안지현 | - |
dc.contributor.AlternativeAuthor | 안새련 | - |
dc.contributor.AlternativeAuthor | 이지은 | - |
dc.contributor.AlternativeAuthor | 윤현석 | - |
dc.contributor.AlternativeAuthor | 박태현 | - |
dc.contributor.AlternativeAuthor | 장정식 | - |
dc.identifier.doi | 10.1038/srep04342 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2014-01/102/0000002410/5 | - |
dc.description.srnd | SEQ:5 | - |
dc.description.srnd | PERF_CD:SNU2014-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000002410 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A002014 | - |
dc.description.srnd | DEPT_CD:458 | - |
dc.description.srnd | CITE_RATE:2.927 | - |
dc.description.srnd | DEPT_NM:화학생물공학부 | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2014-01/102/0000002410/5 | - |
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