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analysis of MAST-CLA results as a diagnostic tool in allergic skin diseases

Cited 13 time in Web of Science Cited 14 time in Scopus
Authors
Shin, Jung Won; Jin, Seon-pil; Lee, Jong Hee; Cho, Soyun
Issue Date
2010-02
Publisher
Korean Dermatological Association
Citation
Annals of Dermatology, Vol.22 No.1, pp. 35-40
Keywords
복합학AllergenAllergic skin diseasesAtopic dermatitisMAST-CLAPruritusSpecific IgEUrticaria
Abstract
Background
Urticaria and atopic dermatitis are representative allergic skin diseases that can be mediated by IgE. Measuring levels of specific IgE can be used to confirm causative agents of these skin diseases.

Objective
To analyze results from the multiple allergosorbent test chemiluminescent assay (MAST-CLA), which measures specific IgE in the presence of a causative agent/allergen, in IgE-mediated skin diseases.

Methods
A total of 404 patients with urticaria, atopic dermatitis or pruritus were enrolled in the present study. Positive rates of specific IgE as well as total serum IgE from the MAST-CLA were compared.

Results
Positive rates of specific IgE were highest in atopic dermatitis patients, followed by urticaria, and then pruritus, with 57.0%, 37.1%, and 20.8%, respectively (p<0.05). House dust mite species were the most common allergens in both atopic dermatitis and urticaria skin diseases. There were no differences in the overall MAST-CLA results between acute and chronic urticaria. The relative positive rate of inhalant allergen was significantly higher in adult than in child atopic dermatitis patients.

Conclusion
Results from the MAST-CLA showed diversity among the three disease groups, and within each disease group, with different positive rates of specific IgE, a different mean allergen number per patient, and so on. Therefore, we concluded that MAST-CLA could be a useful diagnostic tool for various allergic skin diseases.
ISSN
1013-9087
Language
Korean
URI
https://hdl.handle.net/10371/93005
DOI
https://doi.org/10.5021/ad.2010.22.1.35
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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