흉선적출이 면역기능에 미치는 영향

Abstract

Adult thy mectomy in combination with or without whole body irradiation was performed in C,H mice and attempts were made to test the hypothesis that presence of the thymus is necessary for recovery of immune reactivity in adult life. Adult thymectomy didnt induce significant increase in incidence of wasting and mortality rate as well as significant decrease in immune reactivity to transp· lanted liposarcoma. Whole-body irradiation in combination with thymeetomy induced apparently more increase in incidence of wasting and mortality rate as well as much more decrease in peripheral lymphocytes/granulocyte ratio and numbers of LPC in deep cortical area of regional lymph node and periarteriallymphatic sheath of spleen in relation to transplantation of liposarcoma than non-operated group. These observations indicate that thymus is necessary in recovery of immune reactivity in adult life by means of increase in adequate pool of immunologically competent cells.