S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 01 No.1 (1960)
가성 「소-다」에 의한 식도부식증에 관한 실험적연구 -특히 각종 장기의 병리조직학적변화-
Experimental Studies on the Corrosive Esophagitis due to Lye. Especially the Histopathological Observations of several Internal Organs.
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.1 No.1, pp. 5-48
- The experimental caustic effects 011 the rabbits
Esophagus are produced with 2. Occof 5 0% solution
and 5.0cc of 2.0% of Sodium hydroxide solution
The macroscopic and histopathological findings of
Bronchus, Lung, Heart, Esophagus, Stomach, Intes
tine, Liver , Pancreas, Kidney, Adrenal gland, and
Spleen have been persued after this treatment
(1) The results are differently influenced by its
concentration even if same amount of caustic
has been used. Namely, the animals being
treated with high concentration of solution
take fatal courses in a few days.
(2) By 24 hours after the application of caustic on
the Esophagus, dilation, congestion, hyperemia
and rupturing of vascular system develop. At
the same time, the tissue destruction of digestive
organs and other organs, that is, necrosis
and degeneration develops.
(3) In the group treated with 2.0cc of 5.0% caustic
solution, the early findings of Respiratory
systems, Esophagus and Stomach among the
digestiγe organs and Liver are more severe.
(4) In the group treated with 5.0cc of 2.0% caustic
solution, the early findings are severe in
the Heart, Intestine, Pancreas, Urinary Organs
(5) 72 hours after the application of caustic, the morbid change is at its peak, and the healing
mechanism becomes apparent at the end of first
week. At the end of 3 weeks the morbid change
in the Lung, Stomach, Kidney and Adre
nal gland becomes aggravated again. However,
by the end of 5 weeks nearly complete recovery
can be expected in the every organ
(6) The changes in the Esophagus, Stomach and
the part of Intestine due to direct contact
with test solution, are Necrosis, Ulceration,
Granulation tissue formation and Scar tissue
formation. Scar tissue formation starts at about
the end of two weeks.
(7) In the organs except Esophagus, Stomach and
Intestine, dilatation and congestion of capillaries
and small vessels are marked These findingshave
the close relation with clinical shock.
(8) The possibility of direct inflowing of the caustic
solution into the blood stream can not be exc!
uded. However, the cause of tissue changes
other than in the Esophagus, Stomach and
intestine has been considered as the absorption
of substances from tissue destruction in the
Esophagus, Stomach and Intestine