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Bioelectronic Tongue Using Heterodimeric Human Taste Receptor for the Discrimination of Sweeteners with Human-like Performance

Cited 45 time in Web of Science Cited 47 time in Scopus
Authors
Song, Hyun Seok; Jin, Hye Jun; Ahn, Sae Ryun; Kim, Daesan; Lee, Sang Hun; Kim, Un-Kyung; Simons, Christopher T.; Hong, Seunghun; Park, Tai Hyun
Issue Date
2014-10
Publisher
American Chemical Society
Citation
ACS Nano, Vol.8 No.10, pp. 9781-9789
Keywords
복합학bioelectronic tonguehuman sweet taste receptorheterodimeric G-protein-coupled receptorsingle-walled carbon nanotubenanovesicle
Abstract
The sense of taste helps humans to obtain information and form a picture of the world by recognizing chemicals in their environments. Over the past decade, large advances have been made in understanding the mechanisms of taste detection and mimicking its capability using artificial sensor devices. However, the detection capability of previous artificial taste sensors has been far inferior to that of animal tongues, in terms of its sensitivity and selectivity. Herein, we developed a bioelectronic tongue using heterodimeric human sweet taste receptors for the detection and discrimination of sweeteners with human-like performance, where single-walled carbon nanotube field-effect transistors were functionalized with nanovesicles containing human sweet taste receptors and used to detect the binding of sweeteners to the taste receptors. The receptors are heterodimeric G-protein-coupled receptors (GPCRs) composed of human taste receptor type 1 member 2 (hTAS1R2) and human taste receptor type 1 member 3 (hTAS1R3), which have multiple binding sites and allow a human tongue-like broad selectivity for the detection of sweeteners. This nanovesicle-based bioelectronic tongue can be a powerful tool for the detection of sweeteners as an alternative to labor-intensive and time-consuming cell-based assays and the sensory evaluation panels used in the food and beverage industry. Furthermore, this study also allows the artificial sensor to exam the functional activity of dimeric GPCRs.
ISSN
1936-0851
Language
English
URI
https://hdl.handle.net/10371/94315
DOI
https://doi.org/10.1021/nn502926x
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
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