S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 16 No.3 (1975)
뇌혈류량에 영향을 주는 각종인자
Cerebral Blood Flow and its Change by the Various Affectirg Factors in the Dog
- 주종구; 김우겸
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.16 No.3, pp. 184-192
- Cerebral blood flow and cardiovascular hemodynamics
and its change were determined under the various conditions in the dog. Cerebral blood flow
was measured using rotameter and cardiac output
was measured analyzing the saline dilution curve,
recorded on physiograph the extra-arterial conductivity,
using Stewart-Hamilton formula.
1. Cerebral blood flow through the one side of
internal carotid was 57.7 ml in 9 dogs (13. 8- 19. 2
kg body weight). Cardiac index in the dog was
131 ml/min/kg. Arterial blood pressure and
cerebral vascular resistance were 117 mmHg and
2.03 mmHg/ml/min, respectively.
2. Raising the arterial blood pressure up to 164
mmHg by the constant infusion of epinephrine,
cerebral blood flow did not show any significant
change. Lowering the arterial blood pressure
from 146 mmHg to 50 mmHg , by the serial blood
loss from the vein , cerebral blood flow main
tained fairly steady level, however, lower than
68 mmHg of arterial blood pressure, there was
an abrupt decrease of cerebral vascular resistance.
This might suggest that this range of the
pressure might be the autoregulatory limit of
the cerebral circulation.
3. Hyperventilation did not produce any change in
cardiovascular hemodynamics and cerebral blood
flow. On the contrary, breathing with 5% CO,-O,
mixture. cerebral blood flow increased from
60.1 ml/min to 68.6 ml/min, associated with the
pH change from 7.40 of normal to 7. 17, and
49 mmHg of arterial CO, tension.
4. Cerebral blood flow increased most eminently
after the infusion of hydrochloric acid. Cerebral
blood flow increased from 55. I ml!min of normal
to 56.8, 66.9, 99.0 ml/min, respectively, with
the associated decrease of arterial pH from 7.45
of normal to 7.37. 7.26, 7.18. , respectively.
Considering with the hypercapneic effect which
has the same pH value. it appears that metabolic
acidosis has much mote effectiveness to the
cerebral vascular resistance. There was not any
cardiovascular effect in metabolic alkalosis.