위액산도에 미치는 혈액의 pH 및 PCO2의 영향

Abstract

The response of gastric acid secretion during various alterations in acid•base balance was examined in twelve dogs. Metabolic acidosis was induced by infusion of hydrochloric acid. Along with the decrease of blood pH, gastric acid pH decrease eminently. The relationship between concentration of H+ and Na+ plus K+ was clear inversely proportional in the gastric juice. Metabolic alkalosis was induced by infusion of sodium bicarbonate. During metabolic alkalosis, gastric acid pH increased gradually and even higher than blood pH. When respiratory acidosis was induced by inhalatioD of 5% COZ- 0 2 mixture, there was no remarkable change in the gastric acid pH. On the contrary, inducing respiratory alkalosis by hy perventilation, acid gastric pH increased accompanying with the increasing blood pH. The response of gastric acid secretion was negligible, during the complicated disturbance induced by the infusion of hydrochloric acid and simultaneous hyperventilation with no considerable alteration of plasma pH. However, during mixed disturbance, induced by the infusion of sodium bicarbonate and CO,-O, mixture inhalation, there Was an increase in gastric add pH. The above results suggest that the respOnse of gastric acid secretion during the various acid-base disturbances depends primarily upon the effect to the H+ and CI- concentration in the blood. The direct effect of pH value on plasma H+ concentra tion and indirect effect of HCO,- to the plasma CI- concentration were relatively important rather than arterial Pea, .