S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 16 No.4 (1975)
위액산도에 미치는 혈액의 pH 및 PCO2의 영향
The Effect of Various Acid-Base Disturbances on the Gastric Acid Secretion in Dog
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.16 No.4, pp. 207-216
- The response of gastric acid secretion during
various alterations in acid•base balance was
examined in twelve dogs.
Metabolic acidosis was induced by infusion of
hydrochloric acid. Along with the decrease of blood
pH, gastric acid pH decrease eminently. The
relationship between concentration of H+ and Na+
plus K+ was clear inversely proportional in the
Metabolic alkalosis was induced by infusion of
sodium bicarbonate. During metabolic alkalosis,
gastric acid pH increased gradually and even
higher than blood pH.
When respiratory acidosis was induced by inhalatioD
of 5% COZ- 0 2 mixture, there was no remarkable
change in the gastric acid pH. On the
contrary, inducing respiratory alkalosis by hy
perventilation, acid gastric pH increased accompanying
with the increasing blood pH.
The response of gastric acid secretion was
negligible, during the complicated disturbance
induced by the infusion of hydrochloric acid and
simultaneous hyperventilation with no considerable
alteration of plasma pH. However, during mixed
disturbance, induced by the infusion of sodium
bicarbonate and CO,-O, mixture inhalation, there Was an increase in gastric add pH.
The above results suggest that the respOnse of
gastric acid secretion during the various acid-base
disturbances depends primarily upon the effect to
the H+ and CI- concentration in the blood. The
direct effect of pH value on plasma H+ concentra
tion and indirect effect of HCO,- to the plasma
CI- concentration were relatively important rather
than arterial Pea, .