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Concanavalin A 및 방사선 조사 처리한 마우스의 면양적혈구에 대한 입양면역 : Adoptive immune response to sheep RBC in Concanavalin A treated and irradiated mouse
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- Authors
- Issue Date
- 1981-03
- Publisher
- 서울대학교 의과대학
- Citation
- Seoul J Med, Vol.22 No.1, pp. 67-74
- Abstract
- Mice treated with Con A, via the same route as
that of immunization , one or two days prior to immunization
with SRBC showed a significant suppres'
sion of direct PFC response. This immunosuppressive
effect could be reversed by using higher dose of
antigen. Cotreatment of Can A-activated spleen cells
suppressed primary or secondary PFC response of the
irradiated mice adoptively transferred with normal or immunized spleen cells. Normal syngeneic recipient
mice transferred with Con A-activated spleen cells
showed a suppression of primary direct PFC response.
Recipients transfered with Con A-activated thymocytes
showed no effect on PFC response
It is suggested that Con A induced immunosuppressian
of T ·dependent humoral immune response in
mice is at least partly due to the activation of a
subpopulation of T cells, and that the effect is transferred
to syngeneic normal mice with Can A-activated
spleen cells.
- ISSN
- 0582-6802
- Language
- Korean
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