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Concanavalin A 및 방사선 조사 처리한 마우스의 면양적혈구에 대한 입양면역
Adoptive immune response to sheep RBC in Concanavalin A treated and irradiated mouse

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Authors
장우현; 김익상; 이명수; 이승훈
Issue Date
1981-03
Publisher
서울대학교 의과대학
Citation
Seoul J Med, Vol.22 No.1, pp. 67-74
Abstract
Mice treated with Con A, via the same route as
that of immunization , one or two days prior to immunization
with SRBC showed a significant suppres'
sion of direct PFC response. This immunosuppressive
effect could be reversed by using higher dose of
antigen. Cotreatment of Can A-activated spleen cells
suppressed primary or secondary PFC response of the
irradiated mice adoptively transferred with normal or immunized spleen cells. Normal syngeneic recipient
mice transferred with Con A-activated spleen cells
showed a suppression of primary direct PFC response.
Recipients transfered with Con A-activated thymocytes
showed no effect on PFC response
It is suggested that Con A induced immunosuppressian
of T ·dependent humoral immune response in
mice is at least partly due to the activation of a
subpopulation of T cells, and that the effect is transferred
to syngeneic normal mice with Can A-activated
spleen cells.
ISSN
0582-6802
Language
Korean
URI
https://hdl.handle.net/10371/9477
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 22 No.1 (1981)
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