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Thymic low affinity/avidity interaction selects natural Th1 cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Byung Hyun | - |
dc.contributor.author | Park, Hyo Jin | - |
dc.contributor.author | Yum, Hye In | - |
dc.contributor.author | Park, Seung Pyo | - |
dc.contributor.author | Park, Jin Kyun | - |
dc.contributor.author | Kang, Eun Ha | - |
dc.contributor.author | Lee, Jae-Il | - |
dc.contributor.author | Lee, Eun Bong | - |
dc.contributor.author | Park, Chung-Gyu | - |
dc.contributor.author | Jung, Kyeong Cheon | - |
dc.contributor.author | Park, Seong Hoe | - |
dc.date.accessioned | 2015-12-11T09:02:08Z | - |
dc.date.available | 2015-12-11T09:02:08Z | - |
dc.date.created | 2018-10-30 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.citation | Journal of Immunology, Vol.194 No.12, pp.5861-5871 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://hdl.handle.net/10371/94804 | - |
dc.description.abstract | Identification of intrathymic eomesodermin(+) (Eomes(+)) CD4 T cells creates a novel idea that there is more than one way for the generation of innate CD4 T cells. Promyelocytic leukemia zinc finger protein(+) T cells and natural Th17 cells are known to be generated by sensing a high and persistent TCR strength, whereas this is not the case for Eomes(+) CD4 T cells. These cells go through low-level signal during the entire maturation pathway, which subsequently leads to induction of high susceptibility to cytokine IL-4. This event seems to be a major determinant for the generation of this type of cell. These T cells are functionally equivalent to Th1 cells that are present in the periphery, and this event takes place both in transgenic and in wild-type mice. There is additional evidence that this type of Eomes(+) innate CD4 T cell is also present in human cord blood. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | American Association of Immunologists | - |
dc.title | Thymic low affinity/avidity interaction selects natural Th1 cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 강병현 | - |
dc.contributor.AlternativeAuthor | 박효진 | - |
dc.contributor.AlternativeAuthor | 염혜인 | - |
dc.contributor.AlternativeAuthor | 박승표 | - |
dc.contributor.AlternativeAuthor | 박진균 | - |
dc.contributor.AlternativeAuthor | 강은하 | - |
dc.contributor.AlternativeAuthor | 이재일 | - |
dc.contributor.AlternativeAuthor | 이은봉 | - |
dc.contributor.AlternativeAuthor | 박정규 | - |
dc.contributor.AlternativeAuthor | 정경천 | - |
dc.contributor.AlternativeAuthor | 박성회 | - |
dc.identifier.doi | 10.4049/jimmunol.1401628 | - |
dc.citation.journaltitle | Journal of Immunology | - |
dc.identifier.wosid | 000355757800032 | - |
dc.identifier.scopusid | 2-s2.0-84931305583 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2015-01/102/0000000922/1 | - |
dc.description.srnd | ADJUST_YN:N | - |
dc.description.srnd | EMP_ID:D026822 | - |
dc.description.srnd | DEPT_CD:801 | - |
dc.description.srnd | CITE_RATE:4.922 | - |
dc.description.srnd | DEPT_NM:의학과 | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.citation.endpage | 5871 | - |
dc.citation.number | 12 | - |
dc.citation.startpage | 5861 | - |
dc.citation.volume | 194 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Jin Kyun | - |
dc.contributor.affiliatedAuthor | Lee, Jae-Il | - |
dc.contributor.affiliatedAuthor | Lee, Eun Bong | - |
dc.contributor.affiliatedAuthor | Park, Chung-Gyu | - |
dc.contributor.affiliatedAuthor | Jung, Kyeong Cheon | - |
dc.contributor.affiliatedAuthor | Park, Seong Hoe | - |
dc.identifier.srnd | 2015-01/102/0000000922/1 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CD8(+) T-CELLS | - |
dc.subject.keywordPlus | THYMOCYTE-THYMOCYTE INTERACTION | - |
dc.subject.keywordPlus | POSITIVE SELECTION | - |
dc.subject.keywordPlus | INNATE-LIKE | - |
dc.subject.keywordPlus | LINEAGE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SIGNALS | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
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