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Physical Stimuli-Induced Chondrogenic Differentiation of Mesenchymal Stem Cells Using Magnetic Nanoparticles

DC Field Value Language
dc.contributor.authorSon, Boram-
dc.contributor.authorKim, Hwan D.-
dc.contributor.authorKim, Minsoo-
dc.contributor.authorKim, Jeong Ah-
dc.contributor.authorLee, Jinkyu-
dc.contributor.authorShin, Heungsoo-
dc.contributor.authorHwang, Nathaniel S.-
dc.contributor.authorPark, Tai Hyun-
dc.date.accessioned2016-01-28T05:26:33Z-
dc.date.available2016-01-28T05:26:33Z-
dc.date.created2018-06-28-
dc.date.issued2015-06-
dc.identifier.citationAdvanced healthcare materials, Vol.4 No.9, pp.1339-1347-
dc.identifier.issn2192-2640-
dc.identifier.urihttps://hdl.handle.net/10371/95470-
dc.description.abstractChondrogenic commitments of mesenchymal stem cells (MSCs) require 3D cellular organization. Furthermore, recent progresses in bioreactor technology have contributed to the development of various biophysical stimulation platforms for efficient cartilage tissue formation. Here, an approach is reported to drive 3D cellular organization and enhance chondrogenic commitment of bone-marrow-derived human mesenchymal stem cells (BM-hMSCs) via magnetic nanoparticle (MNP)-mediated physical stimuli. MNPs isolated from Magnetospirillum sp. AMB-1 are endocytosed by the BM-hMSCs in a highly efficient manner. MNPs-incorporated BM-hMSCs are pelleted and then subjected to static magnetic field and/or magnet-derived shear stress. Magnetic-based stimuli enhance level of sulfated glycosaminoglycan (sGAG) and collagen synthesis, and facilitate the chondrogenic differentiation of BM-hMSCs. In addition, both static magnetic field and magnet-derived shear stress applied for the chondrogenic differentiation of BM-hMSCs do not show increament of hypertrophic differentiation. This MNP-mediated physical stimulation platform demonstrates a promising strategy for efficient cartilage tissue engineering.-
dc.language영어-
dc.language.isoen-
dc.publisherJohn Wiley and Sons Ltd-
dc.titlePhysical Stimuli-Induced Chondrogenic Differentiation of Mesenchymal Stem Cells Using Magnetic Nanoparticles-
dc.typeArticle-
dc.contributor.AlternativeAuthor손보람-
dc.contributor.AlternativeAuthor김민수-
dc.contributor.AlternativeAuthor김정아-
dc.contributor.AlternativeAuthor이진규-
dc.contributor.AlternativeAuthor신흥수-
dc.contributor.AlternativeAuthor박태현-
dc.identifier.doi10.1002/adhm.201400835-
dc.citation.journaltitleAdvanced healthcare materials-
dc.identifier.wosid000356834000009-
dc.identifier.scopusid2-s2.0-84932197365-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2015-01/102/0000002410/11-
dc.description.srndADJUST_YN:Y-
dc.description.srndEMP_ID:A002014-
dc.description.srndDEPT_CD:458-
dc.description.srndCITE_RATE:5.797-
dc.description.srndDEPT_NM:화학생물공학부-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.citation.endpage1347-
dc.citation.number9-
dc.citation.startpage1339-
dc.citation.volume4-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorHwang, Nathaniel S.-
dc.contributor.affiliatedAuthorPark, Tai Hyun-
dc.identifier.srnd2015-01/102/0000002410/11-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusMECHANOSENSITIVE ION CHANNELS-
dc.subject.keywordPlusMARROW STROMAL CELLS-
dc.subject.keywordPlusARTICULAR-CARTILAGE-
dc.subject.keywordPlusPROGENITOR CELLS-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusCYCLIC-AMP-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusBONE-
dc.subject.keywordPlusCULTURE-
dc.subject.keywordPlusLIMB-
dc.subject.keywordAuthorchondrogenesis-
dc.subject.keywordAuthormagnetic nanoparticles-
dc.subject.keywordAuthormesenchymal stem cells-
dc.subject.keywordAuthorshear stress-
dc.subject.keywordAuthorstatic magnetic fields-
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