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한국인 태아 소뇌의 형태학적 발육에 관한 연구 : Studies on Morphological Development of the Human Fetal Cerebellum

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서울대학교 의과대학
Seoul J Med, Vol.25 No.2, pp. 209-229
To evaluate the morphological development of cerebellum
76 specimens of Korean human fetal cerebel
1um were studied. The fetuses were products of artificial
abortion with the gestational age from 15 to 40
weeks , and were proved to be normal after complete
examination of fetuses and placentas. The weight of
cerebellum and dimensions of anteroposterior diame'
ter , transverse diameter and height of cerebellum were measured. Blocks were taken from 5 different
areas of hemisphere and vermis and analyzed under
light microscope.
The weight of cerebellum increased steadily by
gestational age with a surge at 25~28 weeks of
gestation and reached 7.6% of the total brain weight
by term. The measurements of cerebellum also increased
steadily with the gestational age, and the trans
verse diameter increased more rapidly than the height
of the cerebellum.
Grossly the surface of the cerebellum revealed
characteristic features by the appearance of posterolateral
and primary fissures and foliation. The foliation
became δrst noted at the vermis and then was
followed by anterior and posterior lobes of the hemispheres.
Histological development of cerebellar cortex was
more progressive in vermis than in hemispheres,
anterior or posterior lobe, in genera l. The number
of cell rows and thickness of the external granular
layer decreased at the term of gestation. The thickness
of molecular layer increased in the vermis and
in the posterior lobe of hemisphere from 29~32
weeks and 33~36 weeks of gestation, respectively,
but it showed no significant change in the anterior
lobe of hemisphere.
The Purl이nje cell became morphologically mature
by 33~36 weeks of gestation in the vermis , although
there was a 4 weeks lag in the hemisphere. During
the period of active development the density of Purkinje
cells at the bottom of sulcus was greater than
that at the top of gyrus.
Lamina dissecans was a transient structure that
was recognized after 21~24 weeks of gestation and
disappeared by 29~32 weeks of gestation. The disap
pearance of lamina dissecans in the vermis was earlier
than that in the region of hemisphere.
The number of cell rows and thickness of the
internal granular layer of the developing cerebellar
cortex could not be seperated from the underlying
white matter during 13~20 weeks of gestation in
the anterior and posterior lobes of hemisphere although
it could be recognized during 13~20 weeks at
the region of the vermis. The number of cell rows
and thickness of internal granular layer increased
rapidly after 29~32 weeks of gestation in both hemispheres
and vermis.
Comparing the development of the top of gyrus
and that of the bottom of sulcus, it was apparent
that the number of cell rows and the thickness of
external granular layer at the bottom of sulcus were
greater than those at the top of gyrus , whereas the
number of cell rows and the thickness of internal
granular layer at the top of gyrus were greater than
those at the bottom of sulcus. These observations
were regarded as a mechanism of formation of cereh
ellar folia
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