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동종 뇌하수체 전엽 추출물의 반복주사에 의한 백서 뇌하수체 전염 병변에 관한 병리조직학적 및 혈청학적 연구 : A serologic and histopathologic study on anterior lobe of pituitary in rats immunized with extracts of isologous rat anterior pituitary in Freund's adjuvant and pertussis vaccine
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- Authors
- Issue Date
- 1977-09
- Publisher
- 서울대학교 의과대학
- Citation
- Seoul J Med, Vol.18 No.3, pp. 184-194
- Abstract
- An experimental study was made to develop an
animal model of autoimmune hypophysitis. Thirty
rats were used. They were immunized with extracts
of isologous rat anterior pituitary in Freund's complete
adjuvant together with pertussis vaccine. The
following results were obtained.
Almost all of the pituitary antisera of the animals
tested disclosed single precipitation line with pituitary
extracts with Ouchterlony double diffusion gel technique.
Triiodothyronine (T3) radioimmunoassy of five
immunized rat sera failed to reveal any significant
value compared with that of normal control sera.
In group I animal group. architectures of the anterior
lobe of the pituitary were relatively well preserved
only focally showing minimal lymphocyte infiltration
in three cases, but in group II. conspicuous
lesion could be identified in six cases demonstrating
architectural disconfigurat ion. cytolysis and degranulation
of pituitary parenchymal cells as well as inflammatory
cell (lymphocytes) infiltration.
No specific lesions were noted in other organs and
tissues examined.
The results of this experiment suggest that human
hypophysit.is might be understood along the line of
autoimmunity.
- ISSN
- 0582-6802
- Language
- Korean
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