trans-1, 4, 5, 6 Tetrahydro-2-(3-hydroxystyryI)-1-methylpyrimidine(CP-14,445)의 Trichocephalus trichiurus에 대한 구충효과
Anthelminthic effect of trans-1, 4, 5, 6 Tetrahydro-2-(3-hydroxystyryI)-1-methylpyrimidine(CP-14,445) on Trichocephalus trichiurus
- Park, Chan Woong; Lim, Jung Kyu; Shim, Sang Jung; Kim, Myung Suk; Jeong, Myung-Hee
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.14 No.3, pp. 228-232
- CP-14,445, one of pyrimidine derivative, has been
expected to be a potent antiwhipworm agent for
Trichocephalus trichiurus, and its activity in human
infestation, its side effect , and safety through pre•
liminary trial is the subject of the present study.
In 70 case of Trichocephalus trichiurus infestation
one single oral dose of 10mg/kg of CP•14.445 as a
syrup formulation. produced following results.
CP-14.445 showed negative conversion rate of 63%
for T. trichiurus but its egg reduction rate at 22nd
post-treatment day was 91.5%
For the Ascariasis, no effect was observed with
one single oral dose of 10mg/kg
In all tested cases , one single oral dose of 10 mg/kg
of CP-14,445 was well tolerated and there was no
detectable objective and/or subjective side effect.
Blood chemistry, blood film and urinalysis were
taken in all patients and CP-14,445 was so safe as
to revel that no difference was observed between
pre- and post-treatment with one single oral dose
of 10mg/kg of CP-14,445.