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Matrix metalloproteinase-9 in monocytic myeloid-derived suppressor cells correlate with early infections and clinical outcomes in allogeneic hematopoietic stem cell transplantation
DC Field | Value | Language |
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dc.contributor.author | Lee, Sung-Eun | - |
dc.contributor.author | Lim, Ji-Young | - |
dc.contributor.author | Kim, Tae Woo | - |
dc.contributor.author | Jeon, Young-Woo | - |
dc.contributor.author | Yoon, Jae-Ho | - |
dc.contributor.author | Cho, Byung-Sik | - |
dc.contributor.author | Eom, Ki-Seong | - |
dc.contributor.author | Kim, Yoo-Jin | - |
dc.contributor.author | Kim, Hee-Je | - |
dc.contributor.author | Lee, Seok | - |
dc.contributor.author | Cho, Seok-Goo | - |
dc.contributor.author | Kim, Dong-Wook | - |
dc.contributor.author | Lee, Jong Wook | - |
dc.contributor.author | Min, Woo-Sung | - |
dc.contributor.author | Shin, Dong-Mi | - |
dc.contributor.author | Choi, Eun Young | - |
dc.contributor.author | Min, Chang-Ki | - |
dc.creator | 최은영 | - |
dc.date.accessioned | 2019-04-25T02:07:27Z | - |
dc.date.available | 2020-04-05T02:07:27Z | - |
dc.date.created | 2018-09-18 | - |
dc.date.created | 2018-09-18 | - |
dc.date.created | 2018-09-18 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.citation | Biology of Blood and Marrow Transplantation, Vol.24 No.1, pp.32-42 | - |
dc.identifier.issn | 1083-8791 | - |
dc.identifier.uri | https://hdl.handle.net/10371/150240 | - |
dc.description.abstract | The recovery of myeloid-derived suppressor cells (MDSCs) and its relevance in clinical acute graft-versus-host disease (GVHD) and post-hematopoietic stem cell transplantation (HSCT) infections remain to be fully characterized. We examined the expansion of circulating monocytic (M-) MDSCs and granulocytic (G-) MDSCs at the time of engraftment in 130 patients undergoing allogeneic HSCT (allo-HSCT). Compared with the G-MDSC group, the high M-MDSC group had a higher infection rate within 100 days, along with worse 1-year cumulative incidence of treatment-related mortality (TRM) and 2-year probability of event-free survival (EFS). The frequency of M-MDSCs was associated with preceding severe mucositis. Transcriptome profiling analysis of 2 isolated MDSC subtype showed significantly greater matrix metalloproteinase-9 (MMP-9) expression in M-MDSCs than in G-MDSCs. M-MDSCs produced abundantly more MMP-9. Importantly, compared with G-MDSCs, M-MDSCs isolated from patients post-HSCT had a greater capacity to suppress T cell responses, and MMP-9 blockade more forcefully inhibited their immunosuppressive effect. MMP-9 levels also were associated with the occurrence of infections and with transplantation outcomes. Based on these findings, we identify M-MDSCs as a major contributor to infections early after allo-HSCT and worse clinical outcomes via MMP-9. (C) 2017 American Society for Blood and Marrow Transplantation. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | Elsevier BV | - |
dc.title | Matrix metalloproteinase-9 in monocytic myeloid-derived suppressor cells correlate with early infections and clinical outcomes in allogeneic hematopoietic stem cell transplantation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbmt.2017.08.017 | - |
dc.citation.journaltitle | Biology of Blood and Marrow Transplantation | - |
dc.identifier.wosid | 000419933800007 | - |
dc.identifier.scopusid | 2-s2.0-85030649693 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201825089 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A076144 | - |
dc.description.srnd | CITE_RATE:4.484 | - |
dc.description.srnd | DEPT_NM:의과학과 | - |
dc.description.srnd | EMAIL:eycii@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.citation.endpage | 42 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 32 | - |
dc.citation.volume | 24 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Shin, Dong-Mi | - |
dc.contributor.affiliatedAuthor | Choi, Eun Young | - |
dc.identifier.srnd | T201825089 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | VERSUS-HOST-DISEASE | - |
dc.subject.keywordPlus | BETA-ARRESTIN 2 | - |
dc.subject.keywordPlus | PERIPHERAL-BLOOD | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | ORAL MUCOSITIS | - |
dc.subject.keywordPlus | EXPANSION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CONTRIBUTE | - |
dc.subject.keywordPlus | TOLERANCE | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordAuthor | Matrix metalloproteinase-9 | - |
dc.subject.keywordAuthor | Myeloid-derived suppressor cell | - |
dc.subject.keywordAuthor | Infection | - |
dc.subject.keywordAuthor | Treatment-related mortality | - |
dc.subject.keywordAuthor | Allogeneic hematopoietic stem cell transplantation | - |
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