Rapid Hepatobiliary Excretion of Micelle-Encapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form

Cited 27 time in Web of Science Cited 23 time in Scopus

Seo, Hyo Jung; Nam, Sang Hwan; Im, Hyung-Jun; Park, Ji-Yong; Lee, Ji Youn; Yoo, Byeongjun; Lee, Yun-Sang; Jeong, Jae Min; Hyeon, Taeghwan; Kim, Ji Who; Lee, Jae Sung; Jang, In-Jin; Cho, Joo-Youn; Hwang, Do Won; Suh, Yung Doug; Lee, Dong Soo

Issue Date
Nature Publishing Group
Scientific Reports, Vol.5, p. 15685
In the field of nanomedicine, long term accumulation of nanoparticles (NPs) in the mononuclear phagocyte system (MPS) such as liver is the major hurdle in clinical translation. On the other hand, NPs could be excreted via hepatobiliary excretion pathway without overt tissue toxicity. Therefore, it is critical to develop NPs that show favorable excretion property. Herein, we demonstrated that micelle encapsulated Cu-64-labeled upconverting nanoparticles (micelle encapsulated Cu-64-NOTA-UCNPs) showed substantial hepatobiliary excretion by in vivo positron emission tomography (PET) and also upconversion luminescence imaging (ULI). Ex vivo biodistribution study reinforced the imaging results by showing clearance of 84% of initial hepatic uptake in 72 hours. Hepatobiliary excretion of the UCNPs was also verified by transmission electron microscopy (TEM) examination. Micelle encapsulated Cu-64-NOTA-UCNPs could be an optimal bimodal imaging agent owing to quantifiability of Cu-64, ability of in vivo/ex vivo ULI and good hepatobiliary excretion property.
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