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Mesoporous silica-coated luminescent Eu3+ doped GdVO4 nanoparticles for multimodal imaging and drug delivery
Cited 30 time in
Web of Science
Cited 33 time in Scopus
- Authors
- Issue Date
- 2014-09
- Publisher
- Royal Society of Chemistry
- Citation
- RSC Advances, Vol.4 No.86, pp.45687-45695
- Abstract
- We describe a simple method for synthesizing mesoporous silica-coated luminescent europium-doped gadolinium vanadate (GdVO4:Eu3+@mSiO(2)) nanoparticles. Their biomedical applications as a potential imaging nanoprobe for both fluorescence imaging and magnetic resonance imaging (MRI) and as a simultaneous anti-cancer drug delivery vehicle are also discussed. Eu3+ doped GdVO4 nanoparticles exhibit strong red photoluminescence and the Gd3+ in GdVO4 can be used as a T-1 contrast agent for MRI. T-1-weighted MR contrast enhancement as well as sustained intracellular drug delivery can be achieved by the mesoporous silica layer coating onto a single nanoparticle. Enhanced T-1 MR contrast was proven by relaxometric studies on water access to the paramagnetic core. GdVO4:Eu3+@mSiO(2) nanoparticles as a new type of theragnostic (imaging and treatment) agent can provide new opportunities in a cancer treatment.
- ISSN
- 2046-2069
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