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Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wang, Wenyu | - |
dc.contributor.author | Han, Youngjin | - |
dc.contributor.author | Jo, Hyun A | - |
dc.contributor.author | Lee, Juwon | - |
dc.contributor.author | Song, Yong Sang | - |
dc.date.accessioned | 2020-07-20T01:08:50Z | - |
dc.date.available | 2020-07-20T10:13:05Z | - |
dc.date.issued | 2020-06-05 | - |
dc.identifier.citation | Journal of Hematology & Oncology. 2020 Jun 05;13(1):67 | ko_KR |
dc.identifier.issn | 1756-8722 | - |
dc.identifier.uri | https://hdl.handle.net/10371/168611 | - |
dc.description.abstract | Exosomes are small extracellular vesicles secreted by almost all the cells. Molecular cargos of exosomes can partially reflect the characteristics of originating cells. Exosome-mediated cell-to-cell interactions in the microenvironment are critical in cancer progression. Hypoxia, a key pro-cancerous feature of the tumor microenvironment, alters the releasing and contents of exosomes. A growing body of evidence shows that hypoxia induces more aggressive phenotypes in cancer. Of note, non-coding RNAs shuttled in hypoxic tumor-derived exosomes have been demonstrated as fundamental molecules in regulating cancer biology and remodeling tumor microenvironment. Furthermore, these hypoxic tumor-derived exosomal non-coding RNAs can be detected in the body fluids, serving as promising diagnostic and prognostic biomarkers. The current review discusses changes in cancer behaviors regulated by exosomes-secreted non-coding RNAs under hypoxic conditions. | ko_KR |
dc.description.sponsorship | This work was supported by the grant from Samsung Research Funding Center of Samsung Electronics (project number: SPFC-MA1501-51). WW is a recipient of China Scholarship Council scholarship (CSC number: 201908260030). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Exosomes, Hypoxia | - |
dc.subject | Tumor microenvironment | - |
dc.subject | MiRNA | - |
dc.subject | LncRNA | - |
dc.subject | Non-coding RNA | - |
dc.title | Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 한영진 | - |
dc.contributor.AlternativeAuthor | 조현아 | - |
dc.contributor.AlternativeAuthor | 이주원 | - |
dc.contributor.AlternativeAuthor | 송용상 | - |
dc.identifier.doi | 10.1186/s13045-020-00893-3 | - |
dc.citation.journaltitle | Journal of Hematology & Oncology | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2020-06-16T09:38:18Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 67 | ko_KR |
dc.citation.volume | 13 | ko_KR |
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