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Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment

DC Field Value Language
dc.contributor.authorWang, Wenyu-
dc.contributor.authorHan, Youngjin-
dc.contributor.authorJo, Hyun A-
dc.contributor.authorLee, Juwon-
dc.contributor.authorSong, Yong Sang-
dc.date.accessioned2020-07-20T01:08:50Z-
dc.date.available2020-07-20T10:13:05Z-
dc.date.issued2020-06-05-
dc.identifier.citationJournal of Hematology & Oncology. 2020 Jun 05;13(1):67ko_KR
dc.identifier.issn1756-8722-
dc.identifier.urihttps://hdl.handle.net/10371/168611-
dc.description.abstractExosomes are small extracellular vesicles secreted by almost all the cells. Molecular cargos of exosomes can partially reflect the characteristics of originating cells. Exosome-mediated cell-to-cell interactions in the microenvironment are critical in cancer progression. Hypoxia, a key pro-cancerous feature of the tumor microenvironment, alters the releasing and contents of exosomes. A growing body of evidence shows that hypoxia induces more aggressive phenotypes in cancer. Of note, non-coding RNAs shuttled in hypoxic tumor-derived exosomes have been demonstrated as fundamental molecules in regulating cancer biology and remodeling tumor microenvironment. Furthermore, these hypoxic tumor-derived exosomal non-coding RNAs can be detected in the body fluids, serving as promising diagnostic and prognostic biomarkers. The current review discusses changes in cancer behaviors regulated by exosomes-secreted non-coding RNAs under hypoxic conditions.ko_KR
dc.description.sponsorshipThis work was supported by the grant from Samsung Research Funding Center of Samsung Electronics (project number: SPFC-MA1501-51). WW is a recipient of China Scholarship Council scholarship (CSC number: 201908260030).ko_KR
dc.language.isoenko_KR
dc.publisherBMCko_KR
dc.subjectExosomes, Hypoxia-
dc.subjectTumor microenvironment-
dc.subjectMiRNA-
dc.subjectLncRNA-
dc.subjectNon-coding RNA-
dc.titleNon-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironmentko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor한영진-
dc.contributor.AlternativeAuthor조현아-
dc.contributor.AlternativeAuthor이주원-
dc.contributor.AlternativeAuthor송용상-
dc.identifier.doi10.1186/s13045-020-00893-3-
dc.citation.journaltitleJournal of Hematology & Oncologyko_KR
dc.language.rfc3066en-
dc.rights.holderThe Author(s)-
dc.date.updated2020-06-16T09:38:18Z-
dc.citation.number1ko_KR
dc.citation.startpage67ko_KR
dc.citation.volume13ko_KR
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Agricultural Biotechnology (농생명공학부)Journal Papers (저널논문_농생명공학부)
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