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Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment
Cited 30 time in
Web of Science
Cited 31 time in Scopus
- Authors
- Issue Date
- 2020-06-05
- Publisher
- BMC
- Citation
- Journal of Hematology & Oncology. 2020 Jun 05;13(1):67
- Keywords
- Exosomes, Hypoxia ; Tumor microenvironment ; MiRNA ; LncRNA ; Non-coding RNA
- Abstract
- Exosomes are small extracellular vesicles secreted by almost all the cells. Molecular cargos of exosomes can partially reflect the characteristics of originating cells. Exosome-mediated cell-to-cell interactions in the microenvironment are critical in cancer progression. Hypoxia, a key pro-cancerous feature of the tumor microenvironment, alters the releasing and contents of exosomes. A growing body of evidence shows that hypoxia induces more aggressive phenotypes in cancer. Of note, non-coding RNAs shuttled in hypoxic tumor-derived exosomes have been demonstrated as fundamental molecules in regulating cancer biology and remodeling tumor microenvironment. Furthermore, these hypoxic tumor-derived exosomal non-coding RNAs can be detected in the body fluids, serving as promising diagnostic and prognostic biomarkers. The current review discusses changes in cancer behaviors regulated by exosomes-secreted non-coding RNAs under hypoxic conditions.
- ISSN
- 1756-8722
- Language
- English
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