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Facilitated Transdermal Drug Delivery Using Nanocarriers-Embedded Electroconductive Hydrogel Coupled with Reverse Electrodialysis-Driven Iontophoresis

Cited 15 time in Web of Science Cited 16 time in Scopus
Authors
An, Young-Hyeon; Lee, Joon; Son, Dong Uk; Kang, Dong Hyeon; Park, Mihn Jeong; Cho, Kyoung Won; Kim, Semin; Kim, Su-Hwan; Ko, Junghyeon; Jang, Myoung-Hoon; Lee, Jae Young; Kim, Dae-Hyeong; Hwang, Nathaniel S.
Issue Date
2020-04
Citation
ACS Nano, Vol.14 No.4, pp.4523-4535
Keywords
iontophoresiselectroconductive hydrogelreverse electrodialysisnanocarrierstransdermal drug delivery system
Abstract
We herein developed an iontophoretic transdermal drug delivery system for the effective delivery of electrically mobile drug nanocarriers (DNs). Our system consists of a portable and disposable reverse electrodialysis (RED) battery that generates electric power for iontophoresis through the ionic exchange. In addition, in order to provide a drug reservoir to the RED-driven iontophoretic system, an electroconductive hydrogel composed of polypyrrole-incorporated poly(vinyl alcohol) (PYP) was used. The PYP hydrogel facilitated electron transfer from the RED battery and accelerated the mobility of electrically mobile DNs released from the PYP hydrogel. In this study, we showed that fluconazole- or rosiglitazone-loaded DNs could be functionalized with charge-inducing agents, and DNs with charge modification resulted in facilitated transdermal transport via repulsive RED-driven iontophoresis. In addition, topical application and RED-driven iontophoresis of rosiglitazone-loaded DNs resulted in an effective antiobese condition displaying decreased bodyweight, reduced glucose level, and increased conversion of white adipose tissues to brown adipose tissues in vivo. Consequently, we highlight that this transdermal drug delivery platform would be extensively utilized for delivering diverse therapeutic agents in a noninvasive way.
ISSN
1936-0851
URI
https://hdl.handle.net/10371/171738
DOI
https://doi.org/10.1021/acsnano.0c00007
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
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