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Targeted drug release system based on pH-responsive PAA-POSS nanoparticles
Cited 5 time in
Web of Science
Cited 6 time in Scopus
- Authors
- Issue Date
- 2022-06
- Publisher
- Royal Society of Chemistry
- Citation
- RSC Advances, Vol.12 No.28, pp.18209-18214
- Abstract
- An amphipathic PAA-POSS@DOX drug delivery system that responds sensitively to pH changes in the cancer microenvironment has been developed using a nanoparticle based on inorganic polyhedral oligomeric silsesquioxane (POSS). POSS was introduced to the carboxylic acid group of polyacrylic acid to which doxorubicin anticancer drug was loaded to prepare 480 +/- 192 nm self-assembled nanoparticles. PAA-POSS had a high loading efficiency of over 75% and doxorubicin was quickly released to the target area responding sensitively to weakly acidic conditions. The possibility of employing PAA-POSS as a targeted drug delivery system has been confirmed by observing the death of cells of the MDA-MB-231 breast cancer line.
- ISSN
- 2046-2069
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