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Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans

Cited 28 time in Web of Science Cited 31 time in Scopus

Yang, Suk-Kyun; Hong, Myunghee; Oh, Hyunjung; Low, Hui-Qi; Jung, Seulgi; Ahn, Seonjoo; Kim, Youngjin; Baek, Jiwon; Lee, Cue Hyunkyu; Kim, Eunji; Kim, Kyung Mo; Ye, Byong Duk; Kim, Kyung-Jo; Park, Sang Hyoung; Lee, Ho-Su; Lee, Inchul; Shin, Hyoung Doo; Han, Buhm; McGovern, Dermot P. B.; Liu, Jianjun; Song, Kyuyoung

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W. B. Saunders Co., Ltd.
Gastroenterology, Vol.151 No.6, pp.1096-1099.e3
Recent genome-wide association studies have identified more than 200 regions that affect susceptibility to inflammatory bowel disease (IBD). However, identified common variants account for only a fraction of IBD heritability and largely have been identified in populations of European ancestry. We performed a genome-wide association study of susceptibility loci in Korean individuals, comprising a total of 1505 IBD patients and 4041 controls. We identified 2 new susceptibility loci for IBD at genome-wide significance: rs3766920 near PYGO2-SHC1 at 1q21 and rs16953946 in CDYL2 at 16q23. In addition, we confirmed associations, in Koreans, with 28 established IBD loci (P < 2.16 3 10(-4)). Our findings support the complementary value of genetic studies in different populations.
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  • College of Medicine
  • Department of Medicine
Research Area Bioinformatics, Computational Biology, Genomics, Human Leukocyte Antigen, Statistical Genetics


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