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Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans
Cited 28 time in
Web of Science
Cited 31 time in Scopus
- Authors
- Issue Date
- 2016-12
- Publisher
- W. B. Saunders Co., Ltd.
- Citation
- Gastroenterology, Vol.151 No.6, pp.1096-1099.e3
- Abstract
- Recent genome-wide association studies have identified more than 200 regions that affect susceptibility to inflammatory bowel disease (IBD). However, identified common variants account for only a fraction of IBD heritability and largely have been identified in populations of European ancestry. We performed a genome-wide association study of susceptibility loci in Korean individuals, comprising a total of 1505 IBD patients and 4041 controls. We identified 2 new susceptibility loci for IBD at genome-wide significance: rs3766920 near PYGO2-SHC1 at 1q21 and rs16953946 in CDYL2 at 16q23. In addition, we confirmed associations, in Koreans, with 28 established IBD loci (P < 2.16 3 10(-4)). Our findings support the complementary value of genetic studies in different populations.
- ISSN
- 0016-5085
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