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NK Cell-associated Antigen Expression in Retinoblastoma Animal Model
Cited 10 time in
Web of Science
Cited 3 time in Scopus
- Authors
- Issue Date
- 2013-01
- Publisher
- INFORMA HEALTHCARE
- Citation
- CANCER INVESTIGATION, Vol.31 No.1, pp.72-78
- Abstract
- Natural killer (NK) cells are critical components of our immune system. Herein, we for the first time analyzed the expression and localization of the activating receptor NK cell lectin-like receptor gene 2D (NKG2D) ligands, HLA-G, MICA, MICA/B, and ULBP-2 in orthotopic transplantation models of retinoblastoma. Interestingly, HLA-G and MICA/B were expressed in retinoblastoma cell, whereas MICA and ULBP-2 were not detected. Moreover, HLA-G and MICA/Bwere primarily detected in proliferative area of the tumor periphery with high Ki-67 immunostaining. Our results suggest that NKG2D ligands are differentially expressed in retinoblastoma, which would play a crucial role in immunomodulation in retinoblastoma.
- ISSN
- 0735-7907
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