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Protective effects of vitamin E against 3,3 ',4,4 ',5-pentachlorobiphenyl (PCB126) induced toxicity in zebrafish embryos

Cited 39 time in Web of Science Cited 42 time in Scopus
Authors

Na, Yi-Rang; Seok, Seung-Hyeok; Baek, Min-Won; Lee, Hui-Young; Kim, Dong-Jae; Park, Sung-Hoon; Lee, Hyun-Kyoung; Park, Jae-Hak

Issue Date
2009-03
Publisher
Academic Press
Citation
Ecotoxicology and Environmental Safety, Vol.72 No.3, pp.714-719
Abstract
3.3 ',4,4 ',5-Pentachlorinated biphenyls 126 (PCB126) is a global environmental contaminant that can induce cellular oxidative stress. We investigated whether vitamin E can protect against toxicity from PCB126 during zebrafish (Danio rerio) development. Zebrafish embryos were exposed to 100 nM PCB126 and compared with a second group that was co-exposed with 100 mu M vitamin E until 5 days post fertilization. PCB126 induced pericardial sac edema, yolk sac edema, and growth retardation in zebrafish embyos. In contrast, vitamin E co-exposure group did not show any gross changes. Real-time PCR results showed that vitamin E co-exposure group were restored to control group for the expression levels of heat shock protein 70 Cognate, aryl hydrocarbon receptor type-2, cytochrome P450 1A, and superoxide dismutase-1. These data give insights into the use of vitamin E to reduce PCB126-mediated toxicity and into the use of zebrafish embryos for exploring mechanisms underlying the oxidative potential of AHR agonists. (c) 2008 Elsevier Inc. All rights reserved.
ISSN
0147-6513
URI
https://hdl.handle.net/10371/194831
DOI
https://doi.org/10.1016/j.ecoenv.2008.09.015
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  • College of Veterinary Medicine
  • Department of Veterinary Medicine
Research Area Laboratory Animal Medicine, Toxicologic Pathology

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