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Protective effects of vitamin E against 3,3 ',4,4 ',5-pentachlorobiphenyl (PCB126) induced toxicity in zebrafish embryos
Cited 39 time in
Web of Science
Cited 42 time in Scopus
- Authors
- Issue Date
- 2009-03
- Publisher
- Academic Press
- Citation
- Ecotoxicology and Environmental Safety, Vol.72 No.3, pp.714-719
- Abstract
- 3.3 ',4,4 ',5-Pentachlorinated biphenyls 126 (PCB126) is a global environmental contaminant that can induce cellular oxidative stress. We investigated whether vitamin E can protect against toxicity from PCB126 during zebrafish (Danio rerio) development. Zebrafish embryos were exposed to 100 nM PCB126 and compared with a second group that was co-exposed with 100 mu M vitamin E until 5 days post fertilization. PCB126 induced pericardial sac edema, yolk sac edema, and growth retardation in zebrafish embyos. In contrast, vitamin E co-exposure group did not show any gross changes. Real-time PCR results showed that vitamin E co-exposure group were restored to control group for the expression levels of heat shock protein 70 Cognate, aryl hydrocarbon receptor type-2, cytochrome P450 1A, and superoxide dismutase-1. These data give insights into the use of vitamin E to reduce PCB126-mediated toxicity and into the use of zebrafish embryos for exploring mechanisms underlying the oxidative potential of AHR agonists. (c) 2008 Elsevier Inc. All rights reserved.
- ISSN
- 0147-6513
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