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Stereotypic neutralizing V-H antibodies against SARS-CoV-2 spike protein receptor binding domain in patients with COVID-19 and healthy individuals
DC Field | Value | Language |
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dc.contributor.author | Kim, Sang Il | - |
dc.contributor.author | Noh, Jinsung | - |
dc.contributor.author | Kim, Sujeong | - |
dc.contributor.author | Choi, Younggeun | - |
dc.contributor.author | Yoo, Duck Kyun | - |
dc.contributor.author | Lee, Yonghee | - |
dc.contributor.author | Lee, Hyunho | - |
dc.contributor.author | Jung, Jongtak | - |
dc.contributor.author | Kang, Chang Kyung | - |
dc.contributor.author | Song, Kyoung-Ho | - |
dc.contributor.author | Choe, Pyoeng Gyun | - |
dc.contributor.author | Bin Kim, Hong | - |
dc.contributor.author | Kim, Eu Suk | - |
dc.contributor.author | Kim, Nam-Joong | - |
dc.contributor.author | Seong, Moon-Woo | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Oh, Myoung-don | - |
dc.contributor.author | Kwon, Sunghoon | - |
dc.contributor.author | Chung, Junho | - |
dc.date.accessioned | 2024-04-26T01:00:41Z | - |
dc.date.available | 2024-04-26T01:00:41Z | - |
dc.date.created | 2021-03-15 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.citation | Science Translational Medicine, Vol.13 No.578, p. eabd6990 | - |
dc.identifier.issn | 1946-6234 | - |
dc.identifier.uri | https://hdl.handle.net/10371/199609 | - |
dc.description.abstract | Stereotypic antibody clonotypes exist in healthy individuals and may provide protective immunity against viral infections by neutralization. We observed that 13 of 17 patients with COVID-19 had stereotypic variable heavy chain (V-H) antibody clonotypes directed against the receptor binding domain (RBD) of SARS-CoV-2 spike protein. These antibody clonotypes were composed of immunoglobulin heavy variable 3-53 (IGHV3-53) or IGHV3-66 and immunoglobulin heavy joining 6 (IGHJ6) genes. These clonotypes included IgM, IgG3, IgG1, IgA1, IgG2, and IgA2 subtypes and had minimal somatic mutations, which suggested swift class switching after SARS-CoV-2 infection. The different IGHV chains were paired with diverse light chains resulting in binding to the RBD of SARS-CoV-2 spike protein. Human antibodies specific for the RBD can neutralize SARS-CoV-2 by inhibiting entry into host cells. We observed that one of these stereotypic neutralizing antibodies could inhibit viral replication in vitro using a clinical isolate of SARS-CoV-2. We also found that these V-H clonotypes existed in 6 of 10 healthy individuals, with IgM isotypes predominating. These findings suggest that stereotypic clonotypes can develop de novo from naive B cells and not from memory B cells established from prior exposure to similar viruses. The expeditious and stereotypic expansion of these clonotypes may have occurred in patients infected with SARS-CoV-2 because they were already present. | - |
dc.language | 영어 | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.title | Stereotypic neutralizing V-H antibodies against SARS-CoV-2 spike protein receptor binding domain in patients with COVID-19 and healthy individuals | - |
dc.type | Article | - |
dc.identifier.doi | 10.1126/scitranslmed.abd6990 | - |
dc.citation.journaltitle | Science Translational Medicine | - |
dc.identifier.wosid | 000613948100007 | - |
dc.identifier.scopusid | 2-s2.0-85100648579 | - |
dc.citation.number | 578 | - |
dc.citation.startpage | eabd6990 | - |
dc.citation.volume | 13 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Bin Kim, Hong | - |
dc.contributor.affiliatedAuthor | Kim, Nam-Joong | - |
dc.contributor.affiliatedAuthor | Seong, Moon-Woo | - |
dc.contributor.affiliatedAuthor | Park, Wan Beom | - |
dc.contributor.affiliatedAuthor | Oh, Myoung-don | - |
dc.contributor.affiliatedAuthor | Kwon, Sunghoon | - |
dc.contributor.affiliatedAuthor | Chung, Junho | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SEQUENCE-ANALYSIS | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | IMMUNOGLOBULIN | - |
dc.subject.keywordPlus | RESPONSES | - |
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