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IL-7Rαlow CD8+ T Cells from Healthy Individuals Are Anergic with Defective Glycolysis : IL-7R alpha(low) CD8(+) T Cells from Healthy Individuals Are Anergic with Defective Glycolysis

Cited 5 time in Web of Science Cited 6 time in Scopus
Authors

Sim, Ji Hyun; Kim, Jin-Hee; Park, Ae Kyung; Lee, Jeeyun; Kim, Kyoung-Mee; Shin, Hyun Mu; Kim, Minji; Choi, Kyungho; Choi, Eun Young; Kang, Insoo; Lee, Dong-Sup; Kim, Hang-Rae

Issue Date
2020-12-01
Publisher
American Association of Immunologists
Citation
Journal of Immunology, Vol.205 No.11, pp.2968-2978
Abstract
Effector memory (EM) CD8(+) T cells expressing lower levels of IL-7R alpha (IL-7R alpha(low)) from healthy individuals are partly compromised in vitro, but the identity of these cells has remained unclear. In this study, we demonstrate that human IL-7R alpha(lo)(w) EM CD8(+) T cells are naturally occurring anergic cells in vivo and impaired in proliferation and IL-2 production but competent in IFN-gamma and TNF-alpha production, a state that can be restored by IL-2 stimulation. IL-7R alpha(lo)(w) EM CD8(+) T cells show decreased expression of GATA3 and c-MYC and are defective in metabolic reprogramming toward glycolysis, a process required for the proliferation of T cells. However, IL-7R alpha(lo)(w) EM CD8(+) T cells can proliferate with TCR stimulation in the presence of IL-2 and IL-15, suggesting that these cells can be restored to normality or increased activity by inflammatory conditions and may serve as a reservoir for functional immunity.
ISSN
0022-1767
URI
https://hdl.handle.net/10371/202564
DOI
https://doi.org/10.4049/jimmunol.1901470
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  • College of Medicine
Research Area Function, Immune modulation by metabolites, T-cell anergy, differentiation of memory CD8+ T cells, metabolism

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