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Controlled Delivery of Low-Dose Bone Morphogenetic Protein-2 Using Heparin-Conjugated Fibrin in the Posterolateral Lumbar Fusion of Rabbits

Cited 18 time in Web of Science Cited 20 time in Scopus
Authors

Koo, Ki-Hyoung; Lee, Jong-Min; Ahn, Jung-Min; Kim, Byung-Soo; La, Wan-Geun; Kim, Chang-Sung; Im, Gun-Il

Issue Date
2013-05
Publisher
Blackwell Publishing Inc.
Citation
Artificial Organs, Vol.37 No.5, pp.487-494
Abstract
The heparin-conjugated fibrin (HCF) system has been developed to deliver bone morphogenetic proteins (BMPs) for a long-term period and thus enhance bone regeneration. In the present study, we tested the effectiveness of the delivery system for spinal fusion with a very low dose of BMP-2. A total of 15 rabbits underwent posterolateral lumbar spine, divided into three groups. The control group received only collagen sponges without BMP-2, another group (BMP-only group) received collagen sponges loaded with BMP-2 (10g each side), and the last group (BMP/HCF group) received collagen sponges filled with HCF loaded with BMP-2 (10g each side). All animals were euthanized 8 weeks after surgery, and the fusion was assessed by radiographs, manual palpation, computed tomography scan, and mechanical testing. No case in the BMP/HCF group or in the control group achieved solid fusion, while all cases in BMP-only group showed evidence of solid fusion. BMP/HCF group had significantly lower fusion rate and tensile strength than BMP-only group at the dose of 10g of BMP-2. The HCF long-term delivery system with the low dose of BMP-2 (10g) is ineffective for the induction of lumbar posterolateral fusion in the rabbits.
ISSN
0160-564X
URI
https://hdl.handle.net/10371/204305
DOI
https://doi.org/10.1111/j.1525-1594.2012.01578.x
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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