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Apatite-Coated Porous Poly(lactic-co-glycolic acid) Microspheres as an Injectable Bone Substitute
Cited 16 time in
Web of Science
Cited 17 time in Scopus
- Authors
- Issue Date
- 2010
- Publisher
- TAYLOR & FRANCIS LTD
- Citation
- JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, Vol.21 No.5, pp.635-645
- Abstract
- Previously, we developed an apatite-coated non-porous poly(lactic-co-glycolic acid) (PLGA) microsphere (ANPM) as an injectable bone substitute. We hypothesized that an apatite-coated porous PLGA microsphere (APPM) would have enhanced osteogenic potential compared to that of an ANPM. To test the hypothesis, critical-sized bone defects were made in mouse calvaria, and APPMs and ANPMs were implanted in the defects for 8 weeks. New bone formed around both types of bone substitutes implanted in mouse calvarial defects. Importantly, the portion of bone-like tissue area in the implant cross-sectional area was significantly higher in the APPM group than in the ANPM group (36.9% versus 14.6%, P < 0.001). Fluorochrome-labeling analysis showed that bone regeneration occurred in the pores of implanted APPMs. The results show that APPM may be useful as a bone substitute in orthopedic applications. (C) Koninklijke Brill NV, Leiden, 2010
- ISSN
- 0920-5063
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