Publications
Detailed Information
Mechanical properties and degradation behaviors of hyaluronic acid hydrogels cross-linked at various cross-linking densities
Cited 153 time in
Web of Science
Cited 172 time in Scopus
- Authors
- Issue Date
- 2007-10
- Publisher
- Pergamon Press Ltd.
- Citation
- Carbohydrate Polymers, Vol.70 No.3, pp.251-257
- Abstract
- The effect of cross-linking density of hyaluronic acid (HA) hydrogels on mechanical properties and degradation behaviors has been investigated. HA hydrogels were prepared by the covalent cross-linking of HA with poly(ethylene glycol)-diamine with two different molecular weights at various cross-linking densities. The elastic modulus increased gradually as the theoretical cross-linking density of HA hydrogels increased from 0% to 20%. However, as the theoretical cross-linking density increased above 20%, the elastic modulus decreased. At a theoretical cross-linking density of 20%, the elastic modulus increased as the molecular weight of the cross-linking molecule decreased. In vitro degradation rates of HA hydrogels decreased as the molecular weight of the cross-linking molecule decreased at a theoretical cross-linking density of 20%. The degradation rate of the cross-linked HA hydrogels decreased with increases in the theoretical cross-linking density from 0% to 20%. However, there was no significant difference in the degradation rate as the theoretical cross-linking density increased above 30%. With controllable mechanical properties and degradation rates, the developed HA hydrogels would be further investigated for various medical applications. (c) 2007 Elsevier Ltd. All rights reserved.
- ISSN
- 0144-8617
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.