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Mechanical properties and degradation behaviors of hyaluronic acid hydrogels cross-linked at various cross-linking densities

Cited 153 time in Web of Science Cited 172 time in Scopus
Authors

Jeon, Oju; Song, Su Jin; Lee, Kee-Jung; Park, Moon Hyang; Lee, Soo-Hong; Hahn, Sei Kwang; Kim, Sungjee; Kim, Byung-Soo

Issue Date
2007-10
Publisher
Pergamon Press Ltd.
Citation
Carbohydrate Polymers, Vol.70 No.3, pp.251-257
Abstract
The effect of cross-linking density of hyaluronic acid (HA) hydrogels on mechanical properties and degradation behaviors has been investigated. HA hydrogels were prepared by the covalent cross-linking of HA with poly(ethylene glycol)-diamine with two different molecular weights at various cross-linking densities. The elastic modulus increased gradually as the theoretical cross-linking density of HA hydrogels increased from 0% to 20%. However, as the theoretical cross-linking density increased above 20%, the elastic modulus decreased. At a theoretical cross-linking density of 20%, the elastic modulus increased as the molecular weight of the cross-linking molecule decreased. In vitro degradation rates of HA hydrogels decreased as the molecular weight of the cross-linking molecule decreased at a theoretical cross-linking density of 20%. The degradation rate of the cross-linked HA hydrogels decreased with increases in the theoretical cross-linking density from 0% to 20%. However, there was no significant difference in the degradation rate as the theoretical cross-linking density increased above 30%. With controllable mechanical properties and degradation rates, the developed HA hydrogels would be further investigated for various medical applications. (c) 2007 Elsevier Ltd. All rights reserved.
ISSN
0144-8617
URI
https://hdl.handle.net/10371/204380
DOI
https://doi.org/10.1016/j.carbpol.2007.04.002
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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