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마우스 두개골 결손 모델에서 지방줄기세포와 BMP-2의 골 재생 효능 비교 : Comparison of osteogenic potential between adipose-derived stem cells and BMP-2 in a mouse calvarial defect model

Cited 7 time in Web of Science Cited 0 time in Scopus
Authors

Kang, Sun Woong; La, Wan-Guen; Kang, Jin-Muk; Lee, Jong-Ho; Park, Jung-Ho; Kim, Byung-Soo

Issue Date
2007-09
Publisher
KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC
Citation
TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.4 No.3, pp.382-387
Abstract
In vivo bone regeneration can be achieved either by transplantation of osteogenic cells differentiated from adipose-derived stem cells (ADSCs) or by delivery of exogenous bone morphogenetic protein-2 (BMP-2). In this study, we compared the osteogenic potential between ADSCs and BMP-2 in a mouse calvarial defect model. Critical-sized circular calvarial defects were made in nude mice. The mice were randomized into 4 groups (n=6 per group) that were treated with either 1) fibrin glue alone, 2) fibrin glue with BMP-2, 3) fibrin glue with undifferentiated ADSCs, or 4) fibrin glue with osteogenically differentiated ADSCs. Specimens were harvested at 8 weeks after treatment and evaluated radiographically and histologically. Differentiation of human ADSCs prior to transplantation did not affect bone regeneration. Transplantation of ADSCs was not superior to BMP-2 delivery for in vivo bone formation in a mouse calvarial defect model.
ISSN
1738-2696
URI
https://hdl.handle.net/10371/204381
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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