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Poly(lactic-co-glycolic acid) nanosphere as a vehicle for gene delivery to human cord blood-derived mesenchymal stem cells: comparison with polyethylenimine

Cited 26 time in Web of Science Cited 28 time in Scopus
Authors

Gwak, So-Jung; Kim, Byung Soo

Issue Date
2008-07
Publisher
SPRINGER
Citation
BIOTECHNOLOGY LETTERS, Vol.30 No.7, pp.1177-1182
Abstract
Polyethylenimine (PEI) is one of the most extensively studied non-viral vectors but its cytotoxicity limits its clinical value. PLGA nanospheres are biocompatible and can facilitate sustained release of plasmid DNA. This study compares the cytotoxicity and long-term transgene expression between PLGA nanosphere and PEI. PLGA nanospheres were significantly less cytotoxic than PEI at various concentrations. PLGA nanospheres induced significantly higher transgene expression in vitro for a longer duration (21 days) than PEI. We conclude that PLGA nanospheres have potential as gene delivery vehicles for use in gene therapy for diseases in which a long-term therapeutic gene expression regimen is necessary.
ISSN
0141-5492
URI
https://hdl.handle.net/10371/204542
DOI
https://doi.org/10.1007/s10529-008-9676-7
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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