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The role of transforming growth factor-beta and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury : The role of transforming growth factor-β and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury
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Web of Science
Cited 23 time in Scopus
- Authors
- Issue Date
- 2007-11
- Publisher
- TAYLOR & FRANCIS LTD
- Citation
- CONNECTIVE TISSUE RESEARCH, Vol.48 No.6, pp.309-315
- Abstract
- Bone-tendon junction injuries have poor healing potential. This study evaluated the role of TGF-beta and BMP-2 in a fibrin glue carrier in healing of injuries at bone-tendon junction. Seventy-two skeletally mature male rabbits were divided into 4 groups. The tendo-Achilles was surgically transected at its insertion and reattached with a pullout suture. Group 1 served as a control. In groups 2, 3, and 4, fibrin glue, a mixture of TGF-beta and fibrin glue, and a mixture of BMP-2 and fibrin glue were injected into the bone-tendon junction. The animals were sacrificed at 2, 4 and 8 weeks after surgical procedure. The addition of TGF-beta to fibrin glue did not significantly improve the biomechanical properties of repair tissue. BMP-2 in combination with fibrin glue accelerates healing in a bone-tendon injury and also improves the histological and biomechanical properties of the repair tissue so formed.
- ISSN
- 0300-8207
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