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Borrelidins C-E: New antibacterial macrolides from a saltern-derived halophilic Nocardiopsis sp.
Cited 37 time in
Web of Science
Cited 40 time in Scopus
- Authors
- Issue Date
- 2017-06
- Citation
- Marine Drugs, Vol.15 No.6, p. 166
- Abstract
- Chemical investigation of a halophilic actinomycete strain belonging to the genus Nocardiopsis inhabiting a hypersaline saltern led to the discovery of new 18-membered macrolides with nitrile functionality, borrelidins C-E (1-3), along with a previously reported borrelidin (4). The planar structures of borrelidins C-E, which are new members of the rare borrelidin class of antibiotics, were elucidated by NMR, mass, IR, and UV spectroscopic analyses. The configurations of borrelidines C-E were determined by the interpretation of ROESY NMR spectra, J-based configuration analysis, a modified Mosher's method, and CD spectroscopic analysis. Borrelidins C and D displayed inhibitory activity, particularly against the Gram-negative pathogen Salmonella enterica, and moderate cytotoxicity against the SNU638 and K562 carcinoma cell lines.
- ISSN
- 1660-3397
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