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College of Medicine/School of Medicine (의과대학/대학원)
Microbiology (미생물학전공)
Journal Papers (저널논문_미생물학전공)
Chemokine and cytokine production in susceptible C3H/HeN mice and resistant BALB/c mice during Orientia tsutsugamushi infection
- Authors
- Yun, Ji-Hyun; Koh, Young-Sang; Lee, Keun-Hwa; Hyun, Jin-Won; Choi, Yeon-Joo; Jang, Won-Jong; Park, Kyung-Hee; Cho, Nam-Hyuk; Seong, Seung-Yong; Choi, Myung-Sik; Kim, Ik-Sang
- Issue Date
- 2005-06-21
- Publisher
- Wiley-Blackwell
- Citation
- Microbiol Immunol. 2005;49(6):551-7.
- Keywords
- Animals; Chemokines/*biosynthesis/genetics/metabolism; Cytokines/*biosynthesis/genetics; Interleukin-10/biosynthesis; Interleukin-12/biosynthesis; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; *Orientia tsutsugamushi; Scrub Typhus/etiology/genetics/*immunology; Tumor Necrosis Factor-alpha/biosynthesis/genetics
- Abstract
- To understand the pathogenesis of scrub typhus, we examined chemokine and cytokine production in susceptible (C3H/HeN) and resistant (BALB/c) mice after infection with O. tsutsugamushi Gilliam. C3H/HeN mice produced high levels of chemokines macrophage inflammatory proteins 1 alpha (MIP-1 alpha ), MIP-2, monocyte chemoattractant protein 1 (MCP-1), and cytokines gamma-interferon (IFN-gamma ), interleukin-12 (IL-12), IL-10, and tumor necrosis factor alpha (TNF-alpha ) in response to O. tsutsugamushi infection, compared to BALB/c mice. Chemokine profiles in infected mice correlated well with the kinetics of inflammatory cell infiltration. Hyperproduction of chemokines and cytokines was observed in another susceptible-infection model (BALB/c-Karp). These results suggest that hyperproduction of chemokines and cytokines are associated with susceptibility during O. tsutsugamushi infection.
- ISSN
- 0385-5600 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15965303
http://hdl.handle.net/10371/29821
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