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A novel antiproliferative agent, phenylpyridineylbutenol, isolated from Streptomyces sp

Cited 11 time in Web of Science Cited 13 time in Scopus
Authors
Shin, Choonshik; Lim, Haeyoung; Moon, Sangik; Kim, Seunghyun; Yong, Yeonjoong; Kim, Bum-Joon; Lee, Chul-Hoon; Lim, Yoongho
Issue Date
2006-08-16
Publisher
Elsevier
Citation
Bioorg Med Chem Lett. 2006 Nov 1;16(21):5643-5. Epub 2006 Aug 14.
Keywords
Antineoplastic Agents/chemistry/pharmacologyButanols/chemistry/*pharmacologyCell Proliferation/*drug effectsHela CellsHumansPyridines/chemistry/*pharmacology*Streptomyces
Abstract
A novel compound showing antiproliferative effect was isolated from Streptomyces sp. Its structure was determined based on the interpretation of the NMR spectra, and its conformation was elucidated using molecular modeling and 2D NOESY. It was determined to be (E)-4-phenyl-3-(pyridine-2-yl)but-2-en-1-ol.
ISSN
0960-894X (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16908144

http://hdl.handle.net/10371/36284
DOI
https://doi.org/10.1016/j.bmcl.2006.08.015
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College of Medicine/School of Medicine (의과대학/대학원)Microbiology (미생물학전공)Journal Papers (저널논문_미생물학전공)
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