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갑상선 호르몬의 변조에 따른 흰쥐 임파기관의 조직화학적 변화 : Histochemical Changes of the Rat Lymphatic Organs in Relation with the Altered Status of Thyroxin

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서울대학교 의과대학
Seoul J Med, Vol.18 No.4, pp. 195-204
To observe the effects of thyroxine on the lymphatic
organs, the Sprague-Dawley rats weighing about
200g were classified into 4 groups (Group 1: control,
Group 2: thyroidectomy, Group 3: tyroidectomy plus
thyroxin treatment in the dose of restoring the metabolism
to normal, Group 4: thyroxin treatment in
the dose of inducing hyperthyroidism), and from
each experimental animals thymus, lymph node and
spleen were resected on the Ist, 3rd, 5th and 8th
week and fixed in 10% neutral formalin after measuring
the organ weight.
Each sections were stained with Hematoxylin-Eosin,
Methyl Green Pyronin, PAS and Silver stain and
observed under the light microscopy.
The results are summarized as follows.
1. Weights of the lymphatic organs per body
weight decreased after thyroidectomy and increased
after thyroxin treatment.
2. After thyroxin treatment:
1) Pyronin positive lymphocytes increased in the
corticomedullary junction of thymus, germinal
center of the lymph node and periarteriallympho
cyte sheath of the spleen.
2) PAS positive cells increased in the corticomedullary
junction of thymus.
3) Reticular fibers increased in the medulla of thy
mus and perifollicular region of the lymph node.
4) Hematopoietic cells increased in the red pulp of
3. After thyroidectomy the density of chromatin
in the nucleus of thymocytes decreased, and the
lymphoid follicles decreased in size and number. 4. The results suggested that thyroxin acts as a
mitogen and effects the proliferation and differentiation
of lymphocytes.
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