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Protective effect of triphlorethol-A from Ecklonia cava against ionizing radiation in vitro
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- Authors
- Issue Date
- 2006-03-31
- Publisher
- Japan Radiation Reseach Society
- Citation
- J Radiat Res (Tokyo). 47(1): 61-68
- Keywords
- Algae, Brown/*metabolism ; Animals ; Cell Survival/*drug effects/*radiation effects ; Cricetinae ; Cricetulus ; DNA Damage/*radiation effects ; Dose-Response Relationship, Drug ; Fibroblasts/cytology/drug effects/*physiology/radiation effects ; Gamma Rays ; Lipid Peroxidation/drug effects ; Phloroglucinol/administration & dosage/*analogs & derivatives ; Radiation-Protective Agents/administration & dosage ; Reactive Oxygen Species/*metabolism
- Abstract
- We studied the cytoprotective effect of triphlorethol-A against gamma-ray radiation-induced oxidative stress. In this study, hydrogen peroxide, which is a reactive oxygen species (ROS), was detected using 2',7'-dichlorodihydrofluorescein diacetate (DCF-DA) assay. Triphlorethol-A reduced intracellular hydrogen peroxide generated by gamma-ray radiation. This compound provided protection against radiation-induced membrane lipid peroxidation and cellular DNA damage which are the main targets of radiation-induced damage. Triphlorethol-A protected the cell viability damaged by the radiation through inhibition of apoptosis. Triphlorethol-A reduced the expression of bax and activated caspase 3 induced by radiation, but recovered the expression of bcl-2 decreased by radiation. Taken together, the results suggest that triphlorethol-A protects cells against oxidative damage induced by radiation through reducing ROS.
- ISSN
- 0449-3060 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16571919
https://hdl.handle.net/10371/67901
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