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Finite-difference Time-domain Study on Birefringence Changes of the Axon During Neural Activation
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- Authors
- Issue Date
- 2009-06
- Publisher
- 한국광학회 = Optical Society of Korea
- Citation
- J. Opt. Soc. Korea 13, 272-278 (2009)
- Keywords
- Neural activity ; Birefringence signal ; Neurophysiological origin ; Finite-difference timedomain
- Abstract
- Recently, there has been a growing interest in optical imaging of neural activity because the
optical neuroimaging has considerable advantages over conventional imaging. Birefringence of the
axon has been reported to change during neural activation, but the neurophysiological origin of
the change is still unresolved. This study hypothesizes that the birefringence signal is at least partially
attributed to the transient cellular volume change associated with nerve excitation. To examine
this hypothesis, we investigated how the intensity of cross-polarized light transmitting through the
axon would change as the size of the axon changes. For this purpose, a two-dimensional finitedifference
time-domain program was developed with the improvement of the total-field/scatteredfield
method which reduces numerical noise. The results support our hypothesis in that the computed
cross-polarized signals exhibit some agreement with previously-reported birefringence signals.
- ISSN
- 1226-4776
- Language
- English
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