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Finite-difference Time-domain Study on Birefringence Changes of the Axon During Neural Activation

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Authors
Lee, Jonghwan; Kim, Sung June
Issue Date
2009-06
Publisher
한국광학회 = Optical Society of Korea
Citation
J. Opt. Soc. Korea 13, 272-278 (2009)
Keywords
Neural activityBirefringence signalNeurophysiological originFinite-difference timedomain
Abstract
Recently, there has been a growing interest in optical imaging of neural activity because the
optical neuroimaging has considerable advantages over conventional imaging. Birefringence of the
axon has been reported to change during neural activation, but the neurophysiological origin of
the change is still unresolved. This study hypothesizes that the birefringence signal is at least partially
attributed to the transient cellular volume change associated with nerve excitation. To examine
this hypothesis, we investigated how the intensity of cross-polarized light transmitting through the
axon would change as the size of the axon changes. For this purpose, a two-dimensional finitedifference
time-domain program was developed with the improvement of the total-field/scatteredfield
method which reduces numerical noise. The results support our hypothesis in that the computed
cross-polarized signals exhibit some agreement with previously-reported birefringence signals.
ISSN
1226-4776
Language
English
URI
http://hdl.handle.net/10371/7430
DOI
https://doi.org/10.3807/JOSK.2009.13.2.272
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Electrical and Computer Engineering (전기·정보공학부)Journal Papers (저널논문_전기·정보공학부)
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