S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 11 No.3 (1970)
포도구균 및 녹농균의 실험적 혼합감염증에 미치는 접종시간 간격의 영향
Influences of time lapse in introduction into body upon the experimentel mixed infections of Staph. aureus and Ps. aeruginosa.
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.11 No.4, pp. 19-26
- Of late it was roported that the cases of mixed
bactorial infections, due to Staph. aureus, Es. coli,
the proteus, the pseudomonas and others, are
The exact mechanilms, however, of mixed infections
are not well cIearified.
It was thought that the time lapse in bacterial
introduction into body tissue might produce signifcant
influences on the course of infections. To investigate
this possibliity, Staph. au reus and Ps, aeruginosa
were cultercd aerobically in Brain-Heart Infusion Broth
at 37°C. and inoculated into ear vein of rabbits
together with, or with time lapse of 1 hour or 24
+011 i:: it oI "6" uJ s1;<] Z1 'V;.:il
.k% Ps. aeruginosa i:: 3°.1 7iJ 7J}7'j ~7} 6j-.:il a: .f.
~ 7'\l71~;>;1 t:!l;\1].£.- ~7Jol 'ict~ it4- °1':ct4·
2. !£."-Tit 1:J * 1 "'17,} + Ps. aeruginasa 1:J *.;c
The heart blood and the urire were taken asoptically
and the viable units number of both species in the
specimons were followed.
The resilts of observation might be summerized as follows.
1. When the stophylococci and the pseudomonas
were inoculated simultaneously, ; From the blood stream
the viable units of both species disappecred raiidly, The
viable units of staphylococcus in the unine initiated
marked increase after 2-3 days of infection and
continued through 7 days.
The viable units of pseudomonas in the urine increased
slowly until the 3rd day and then showed no
noticiable increase or decrease through the 7th day.
2. When the psedomonas were inoculated 1 hour
after the inoculation of staphylococci'; The population
curve patterns of both bacterial species in both blood
and unine were almost same with those of the
simultaneous inocuation group.
3. When the pseudomones were inoculated 24 hours
after the inoculation of staphylococci'; The staphylococci
disappeared rapidly from the blood, but showed
small and transient increase after the inoculation of
The staphylococci in the urire increased rapidly,
without intial delay, until the 3rd day, no noticiable
change in numbor until the 5th day, and then
The psoudomonas in the blood disappeared rapidly
from the blood and could not be recovered after 1
day through 7 days. The pseudomonas in the uri no
showed small but persistont number until the 4th day
and some increase after that.