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Regulation of morphogenesis and neural differentiation of human mesenchymal stem cells using carbon nanotube sheets

Cited 32 time in Web of Science Cited 37 time in Scopus
Authors
Kim, Jeong Ah; Jang, Eui Yun; Kang, Tae June; Yoon, Sungjun; Ovalle-Robles, Raquel; Rhee, Won Jong; Kim, Taewoo; Baughman, Ray H.; Kim, Yong Hyup; Park, Tai Hyun
Issue Date
2012-06
Publisher
The Royal Society of Chemistry
Citation
Integrative Biology Vol.4 No.6, pp. 587-594
Keywords
자연과학
Abstract
In order to successfully utilize stem cells for therapeutic applications in regenerative medicine, efficient differentiation into a specific cell lineage and guidance of axons in a desired direction is crucial. Here, we used aligned multi-walled carbon nanotube (MWCNT) sheets to differentiate human mesenchymal stem cells (hMSCs) into neural cells. Human MSCs present a preferential adhesion to aligned CNT sheets with longitudinal stretch parallel to the CNT orientation direction. Cell elongation was 2-fold higher than the control and most of the cells were aligned on CNT sheets within 51 from the CNT orientation direction. Furthermore, a significant, synergistic enhancement of neural differentiation was observed in hMSCs cultured on the CNT sheets. Axon outgrowth was also controlled using nanoscale patterning of CNTs. This CNT sheet provides a new cellular scaffold platform that can regulate morphogenesis and differentiation of stem cells, which could open up a new approach for tissue and stem cell regeneration.
ISSN
1757-9694
Language
English
URI
https://hdl.handle.net/10371/83133
DOI
https://doi.org/10.1039/c2ib20017a
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
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