S-Space College of Engineering/Engineering Practice School (공과대학/대학원) Dept. of Electrical and Computer Engineering (전기·정보공학부) Journal Papers (저널논문_전기·정보공학부)
The topographical guidance of neurons cultured on holographic photo-responsive polymer
- Lee, Jae Kyoo; Baac, Hyoungwon; Song, Sang-Ho; Lee, Sin-Doo; Park, Dongeon
- Issue Date
- The 26th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBS), pp. 4970-4973, San Francisco, California, USA, September 1-5, 2004
- Neuronal cells to respond to submicron-scale groove structure. On the grooved structure of particular dimension, it has been reported that neuronal cells grew perpendicular to the groove direction. We used holographic photo-responsive polymer to form a submicron-scale surface relief grating structure. A sinusoidal groove pattern is built up by holographic interference of 488 nm Ar ion laser beams. The primary hippocampal neurons cultured on the surface of the polymer film grew extending their neurites in a perpendicular orientation to the groove direction. This suggests that laser holography can be used to control the neurites orientation and growth. The holographic grating and photo-responsive polymer will raise the possibility of controlling neural network formation between living cells by light.