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Thymic low affinity/avidity interaction selects natural Th1 cells
Cited 5 time in
Web of Science
Cited 5 time in Scopus
- Authors
- Issue Date
- 2015-06
- Publisher
- American Association of Immunologists
- Citation
- Journal of Immunology, Vol.194 No.12, pp.5861-5871
- Abstract
- Identification of intrathymic eomesodermin(+) (Eomes(+)) CD4 T cells creates a novel idea that there is more than one way for the generation of innate CD4 T cells. Promyelocytic leukemia zinc finger protein(+) T cells and natural Th17 cells are known to be generated by sensing a high and persistent TCR strength, whereas this is not the case for Eomes(+) CD4 T cells. These cells go through low-level signal during the entire maturation pathway, which subsequently leads to induction of high susceptibility to cytokine IL-4. This event seems to be a major determinant for the generation of this type of cell. These T cells are functionally equivalent to Th1 cells that are present in the periphery, and this event takes place both in transgenic and in wild-type mice. There is additional evidence that this type of Eomes(+) innate CD4 T cell is also present in human cord blood.
- ISSN
- 0022-1767
- Language
- English
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