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Thymic Low Affinity/Avidity Interaction Selects Natural Th1 Cells

Cited 4 time in Web of Science Cited 4 time in Scopus
Authors
Kang, Byung Hyun; Park, Hyo Jin; Yum, Hye In; Park, Seung Pyo; Park, Jin Kyun; Kang, Eun Ha; Lee, Jae-Il; Lee, Eun Bong; Park, Chung-Gyu; Jung, Kyeong Cheon; Park, Seong Hoe
Issue Date
2015
Publisher
American Association of Immunologists
Citation
Journal of Immunology, vol.194, pp. 5861-5871
Abstract
Identification of intrathymic eomesodermin+ (Eomes+) CD4 T cells creates a novel idea that there is more than one way for the
generation of innate CD4 T cells. Promyelocytic leukemia zinc finger protein+ T cells and natural Th17 cells are known to be
generated by sensing a high and persistent TCR strength, whereas this is not the case for Eomes+ CD4 T cells. These cells go
through low-level signal during the entire maturation pathway, which subsequently leads to induction of high susceptibility to
cytokine IL-4. This event seems to be a major determinant for the generation of this type of cell. These T cells are functionally
equivalent to Th1 cells that are present in the periphery, and this event takes place both in transgenic and in wild-type mice. There
is additional evidence that this type of Eomes+ innate CD4 T cell is also present in human cord blood.
ISSN
0022-1767
Language
English
URI
http://hdl.handle.net/10371/94804
DOI
https://doi.org/10.4049/jimmunol.1401628
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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