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Showing results 361 to 418 of 418

Issue Date	Title / Author(s) / Citation	File
2019-05	Src-mediated phosphorylation, ubiquitination and degradation of Caveolin-1 promotes breast cancer cell stermness Yoon, Hyo-Jin; Kim, Do-Hee; Kim, Su-Jung; Jang, Jeong-Hoon; Surh, Young-Joon Cancer Letters, Vol.449, pp.8-19	DOI
2019-05	15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression Lee, Eun Ji; Kim, Su-Jung; Hahn, Young-Il; Yoon, Hyo-Jin; Han, Bitnara; Kim, Kyeojin; Lee, Seungbeom; Kim, Kwang Pyo; Suh, Young Ger; Na, Hye-Kyung; Surh, Young Joon Redox Biology, Vol.23, p. 101175	DOI
2019-06	Effects of 17β-estradiol on colorectal cancer development after azoxymethane/dextran sulfate sodium treatment of ovariectomized mice Song, Chin-Hee; Kim, Nayoung; Lee, Sun Min; Nam, Ryoung Hee; Choi, Soo In; Kang, So Ra; Shin, Eun; Lee, Dong Ho; Lee, Ha-Na; Surh, Young-Joon Biochemical Pharmacology, Vol.164, pp.139-151	DOI
2019-06	Ajoene, a Major Organosulfide Found in Crushed Garlic, Induces NAD(P)H: quinone Oxidoreductase Expression Through Nuclear Factor E2-related Factor-2 Activation in Human Breast Epithelial Cells Cho, Seung-Ju; Ryu, Jae-Ha; Surh, Young-Joon 대한암예방학회지, Vol.24 No.2, pp.112-122	DOI
2019-06	Baicalein Inhibits Dextran Sulfate Sodium-induced Mouse Colitis Zhong, Xiancai; Surh, Young-Joon; Do, Seon-Gil; Shin, Eunju; Shim, Kyu-Suk; Lee, Chong-Kil; Na, Hye-Kyung 대한암예방학회지, Vol.24 No.2, pp.129-138	DOI
2019-07	The standardized Korean Red Ginseng extract and its ingredient ginsenoside Rg3 inhibit manifestation of breast cancer stem cell-like properties through modulation of self-renewal signaling Oh, Jisun; Yoon, Hyo-Jin; Jang, Jeong-Hoon; Kim, Do-Hee; Surh, Young-Joon Journal of Ginseng Research, Vol.43 No.3, pp.421-430	DOI
2019-07	Cellular adaptation mediated through Nrf2-induced glutamate cysteine ligase up-regulation against oxidative stress caused by iron overload in beta-thalassemia/HbE patients Somparn, Nuntiya; Prawan, Auemduan; Senggunprai, Laddawan; Kukongviriyapan, Upa; Jetsrisuparb, Arunee; Lee, Mee-Hyun; Kim, Do-Hee; Kukongviriyapan, Veerapol; Surh, Young-Joon Free Radical Research, Vol.53 No.7, pp.791-799	DOI
2019-08	17-β estradiol exerts anti-inflammatory effects through activation of Nrf2 in mouse embryonic fibroblasts Song, Chin-Hee; Kim, Nayoung; Kim, Do-Hee; Lee, Ha-Na; Surh, Young-Joon PLoS ONE, Vol.14 No.8, p. e0221650	DOI
2019-12	Genistein Inhibits Proliferation of BRCA1 Mutated Breast Cancer Cells: The GPR30-Akt Axis as a Potential Target Kim, Ga Yun; Suh, Jinyoung; Jang, Jeong-Hoon; Kim, Do-Hee; Park, Ock Jin; Park, Sue K.; Surh, Young-Joon 대한암예방학회지, Vol.24 No.4, pp.197-207	DOI
2019-12	Carbon monoxide ameliorates acetaminophen-induced liver injury by increasing hepatic HO-1 and Parkin expression Chen, Yingqing; Park, Hyeok-Jun; Park, Jeongmin; Song, Hyun-Chul; Ryter, Stefan W.; Surh, Young-Joon; Kim, Uh-Hyun; Joe, Yeonsoo; Chung, Hun Taeg FASEB Journal, Vol.33 No.12, pp.13905-13919	DOI
2020	Modulation of cancer cell growth and progression by Caveolin-1 in the tumor microenvironment Yoon, Hyo-Jin; Surh, Young-Joon Advances in Experimental Medicine and Biology, Vol.1277, pp.63-74	DOI
2020-01	17-Oxo-docosahexaenoic acid induces Nrf2-mediated expression of heme oxygenase-1 in mouse skin in vivo and in cultured murine epidermal cells Jamil, Muhammad Usman; Kim, Jimin; Yum, Hye-Won; Kim, Seong Hoon; Kim, Su-Jung; Kim, Do-Hee; Cho, Nam-Chul; Na, Hye-Kyung; Surh, Young-Joon Archives of Biochemistry and Biophysics, Vol.679, p. 108156	DOI
2020-01	15-Keto prostaglandin E2 induces heme oxygenase-1 expression through activation of Nrf2 in human colon epithelial CCD 841 CoN cells Lee, Jeong-Eun; Zhong, Xiancai; Lee, Ja-Young; Surh, Young-Joon; Na, Hye-Kyung Archives of Biochemistry and Biophysics, Vol.679, p. 108162	DOI
2020-03	Breast Cancer Cell-Derived Soluble CD44 Promotes Tumor Progression by Triggering Macrophage IL1 beta Production Jang, Jeong-Hoon; Kim, Do-Hee; Lim, Jae Min; Lee, JoonWon; Jeong, Su Jin; Kim, Kwang Pyo; Surh, Young-Joon Cancer Research, Vol.80 No.6, pp.1342-1356	DOI
2020-03	Effects of Genetic and Pharmacologic Inhibition of COX-2 on Colitis-associated Carcinogenesis in Mice Lee, Jeong-Sang; Kim, Hyun Soo; Hahm, Ki Baik; Surh, Young-Joon 대한암예방학회지, Vol.25 No.1, pp.27-37	view file DOI
2020-03	17β-estradiol reduces inflammation and modulates antioxidant enzymes in colonic epithelial cells Son, Hee Jin; Kim, Nayoung; Song, Chin-Hee; Lee, Sun Min; Lee, Ha-Na; Surh, Young-Joon The Korean Journal of Internal Medicine, Vol.35 No.2, pp.310-319	view file DOI
2020-03	Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification Shin, Jun Wan; Chun, Kyung-Soo; Kim, Do-Hee; Kim, Su-Jung; Kim, Seong Hoon; Cho, Nam-Chul; Na, Hye-Kyung; Surh, Young-Joon Biochemical Pharmacology, Vol.173, p. 113820	DOI
2020-05	Progress in heme oxygenase research Surh, Young-Joon; Chung, Hun Taeg; Na, Hye-Kyung; Dulak, Jozef; Stec, David E. Archives of Biochemistry and Biophysics, Vol.685, p. 108321	view file DOI
2020-05	Preventive effects of Korean red ginseng on experimentally induced colitis and colon carcinogenesis Shin, Hoon-Jeong; Kim, Do-Hee; Zhong, Xiancai; Yum, Hye-Won; Kim, Su-Jung; Chun, Kyung-Soo; Na, Hye-Kyung; Surh, Young-Joon Journal of Traditional and Complementary Medicine, Vol.10 No.3, pp.198-206	view file DOI
2020-06	Ninjurin1 deficiency aggravates colitis development by promoting M1 macrophage polarization and inducing microbial imbalance Choi, Hoon; Bae, Sung-Jin; Choi, Garam; Lee, Hyunseung; Son, Taekwon; Kim, Jeong-gyun; An, Sunho; Lee, Hye Shin; Seo, Ji Hae; Kwon, Hyouk-Bum; Jeon, Sejin; Oh, Goo Taeg; Surh, Young-Joon; Kim, Kyu-Won FASEB Journal, Vol.34 No.6, pp.8702-8720	DOI
2020-06	15-Deoxy-Δ12,14-prostaglandin J2 Induces Apoptosis in Ha-ras-transformed Human Breast Epithelial Cells by Targeting IκB kinase–NF-κB Signaling Na, Hye-Kyung; Yang, Hongkyung; Surh, Young-Joon 대한암예방학회지, Vol.25 No.2, pp.100-110	view file DOI
2020-06	Nuclear Factor Erythroid-Derived 2-Like 2-Induced Reductive Stress Favors Self-Renewal of Breast Cancer Stem-Like Cells via the FoxO3a-Bmi-1 Axis Kim, Do-Hee; Jang, Jeong-Hoon; Kwon, Ok-Seon; Cha, Hyuk-Jin; Youn, Hyo-Jin; Chun, Kyung-Soo; Surh, Young-Joon Antioxidants and Redox Signaling, Vol.32 No.18, pp.1313-1329	DOI
2020-07	17β-Estradiol supplementation changes gut microbiota diversity in intact and colorectal cancer-induced ICR male mice Song, Chin-Hee; Kim, Nayoung; Nam, Ryoung Hee; Choi, Soo In; Lee, Ha-Na; Surh, Young-Joon Scientific Reports, Vol.10 No.1, p. 12283	DOI
2020-08	Resveratrol suppresses gastric cancer cell proliferation and survival through inhibition of PIM-1 kinase activity Kim, Sujin; Kim, Wonki; Kim, Do-Hee; Jang, Jeong-Hoon; Kim, Su-Jung; Park, Sin-Aye; Hahn, Hyunggu; Han, Byung Woo; Na, Hye-Kyung; Chun, Kyung-Soo; Choi, Bu Young; Surh, Young-Joon Archives of Biochemistry and Biophysics, Vol.689, p. 108413	DOI
2020-09	Gremlin-1 augments the oestrogen-related receptor α signalling through EGFR activation: implications for the progression of breast cancer Park, Sin-Aye; Sung, Nam Ji; Choi, Bae-Jung; Kim, Wonki; Kim, Seung Hyeon; Surh, Young-Joon British Journal of Cancer, Vol.123 No.6, pp.988-999	DOI
2020-09	15-Deoxy-Δ12,14-prostaglandin J2 Induces Epithelial-tomesenchymal Transition in Human Breast Cancer Cells and Promotes Fibroblast Activation Choi, Jeehye; Suh, Jin-Young; Kim, Do-Hee; Na, Hye-Kyung; Surh, Young-Joon 대한암예방학회지, Vol.25 No.3, pp.152-163	view file DOI
2020-09	Fibroblast growth factor-2, derived from cancer-associated fibroblasts, stimulates growth and progression of human breast cancer cells via FGFR1 signaling Suh, Jinyoung; Kim, Do-Hee; Lee, Yeon-Hwa; Jang, Jeong-Hoon; Surh, Young-Joon Molecular Carcinogenesis, Vol.59 No.9, pp.1028-1040	DOI
2020-09	H-Ras induces Nrf2-Pin1 interaction: Implications for breast cancer progression Saeidi, Soma; Kim, Su-Jung; Han, Hyeong-jun; Kim, Seong Hoon; Zheng, Jie; Lee, Han-Byoel; Han, Wonshik; Noh, Dong-Young; Na, Hye-Kyung; Surh, Young-Joon Toxicology and Applied Pharmacology, Vol.402, p. 115121	DOI
2020-09	Helicobacter pylori infection induces STAT3 phosphorylation on Ser727 and autophagy in human gastric epithelial cells and mouse stomach Piao, Juan-Yu; Kim, Su-Jung; Kim, Do-Hee; Park, Ji Hyun; Park, Sin-Aye; Han, Hyeong-jun; Na, Hye-Kyung; Yoon, Kichul; Lee, Ha-Na; Kim, Nayoung; Hahm, Ki Baik; Surh, Young-Joon Scientific Reports, Vol.10 No.1, p. 15711	view file DOI
2020-10	An Electrophilic Deguelin Analogue Inhibits STAT3 Signaling in H-Ras-Transformed Human Mammary Epithelial Cells: The Cysteine 259 Residue as a Potential Target Hong, Sung-Jun; Kim, Jin-Tae; Kim, Su-Jung; Cho, Nam-Chul; Kim, Kyeojin; Lee, Seungbeom; Suh, Young-Ger; Cho, Kyung-Cho; Kim, Kwang Pyo; Surh, Young-Joon Biomedicines, Vol.8 No.10, pp.407-15	view file DOI
2020-11	Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR-γ and SOCS1 induction Park, Jong Min; An, Jeong Min; Han, Young Min; Surh, Young Joon; Hwang, Sun Jin; Kim, Seong Jin; Hahm, Ki Baik Journal of Clinical Biochemistry and Nutrition, Vol.67 No.3, pp.248-256	DOI
2020-11	Breast cancer cell debris diminishes therapeutic efficacy through heme oxygenase-1-mediated inactivation of M1-like tumor-associated macrophages Kim, Seung Hyeon; Saeidi, Soma; Zhong, Xiancai; Gwak, Shin-Young; Muna, Shrat Aklima; Park, Sin-Aye; Kim, Seong Hoon; Na, Hye-Kyung; Joe, Yeonsoo; Chung, Hun Taeg; Kim, Kyoung-Eun; Han, Wonshik; Surh, Young-Joon Neoplasia, Vol.22 No.11, pp.606-616	view file DOI
2020-11	Isoflavone intake on the risk of overall breast cancer and molecular subtypes in women at high risk for hereditary breast cancer Sim, Eun Ji; Ko, Kwang-Pil; Ahn, Choonghyun; Park, Sang Min; Surh, Young-Joon; An, Seokyung; Kim, Sung-Won; Lee, Min-Hyuk; Lee, Jong Won; Lee, Jeong Eon; Kim, Ku Sang; Yom, Cha Kyong; Kim, Hyun-Ah; Park, Sue K. Breast Cancer Research and Treatment, Vol.184 No.2, pp.615-626	DOI
2020-11	Curcumin induces expression of 15-hydroxyprostaglandin dehydrogenase in gastric mucosal cells and mouse stomach in vivo: AP-1 as a potential target Woo, Jeong-Hwa; Park, Jong-Min; Jang, Ji-Hye; Yang, Hongkyung; Surh, Young-Joon; Na, Hye-Kyung Journal of Nutritional Biochemistry, Vol.85, p. 108469	DOI
2020-12	CO ameliorates cellular senescence and aging by modulating the miR-34a/Sirt1 pathway Park, Jeongmin; Kim, Jin; Chen, Yingqing; Song, Hyun-Chul; Chen, Yubing; Zheng, Min; Surh, Young-Joon; Kim, Uh-Hyun; Park, Jeong Woo; Joe, Yeonsoo; Chung, Hun Taeg Free Radical Research, Vol.54 No.11-12, pp.848-858	DOI
2020-12	Gremlin-1 Promotes Metastasis of Breast Cancer Cells by Activating STAT3-MMP13 Signaling Pathway Sung, Nam Ji; Kim, Na Hui; Surh, Young-Joon; Park, Sin-Aye International Journal of Molecular Sciences, Vol.21 No.23, pp.9227-15	DOI
2020-12	Interaction between Peptidyl-prolyl Cis-trans Isomerase NIMA-interacting 1 and GTP-H-Ras: Implications for Aggressiveness of Human Mammary Epithelial Cells and Drug Resistance Saeidi, Soma; Joo, Sihyung; Kim, Su-Jung; Jagadeesh, Achanta Sri Venkata; Surh, Young-Joon 대한암예방학회지, Vol.25 No.4, pp.234-243	DOI
2020-12	17β-Estradiol strongly inhibits azoxymethane/dextran sulfate sodium-induced colorectal cancer development in Nrf2 knockout male mice Song, Chin-Hee; Kim, Nayoung; Hee Nam, Ryoung; In Choi, Soo; Hee Son, Joo; Eun Yu, Jeong; Shin, Eun; Lee, Ha-Na; Kim, Do-Hee; Surh, Young-Joon Biochemical Pharmacology, Vol.182, p. 114279	DOI
2020-12	GSK-3β inhibition by curcumin mitigates amyloidogenesis via TFEB activation and anti-oxidative activity in human neuroblastoma cells Song, Hyun-Chul; Chen, Yubing; Chen, Yingqing; Park, Jeongmin; Zheng, Min; Surh, Young-Joon; Kim, Uh-Hyun; Park, Jeong Woo; Yu, Rina; Chung, Hun Taeg; Joe, Yeonsoo Free Radical Research, Vol.54 No.11-12, pp.1-13	DOI
2020-12	The positive feedback loop between Nrf2 and phosphogluconate dehydrogenase stimulates proliferation and clonogenicity of human hepatoma cells Ong, Athena Jessica; Saeidi, Soma; Chi, Ngo Hoang Kieu; Kim, Su Jung; Kim, Do-Hee; Kim, Seung Hyeon; Park, Sin-Aye; Cha, Young-Nam; Na, Hye-Kyung; Surh, Young-Joon Free Radical Research, Vol.54 No.11-12, pp.1-12	DOI
2020-12	The peptidyl prolyl isomerase, PIN1 induces angiogenesis through direct interaction with HIF-2α Choi, Min-A; Saeidi, Soma; Han, Hyeong-jun; Kim, Su-Jung; Kwon, Nayoung; Kim, Do-Hee; Min, Sang-Hyun; Choi, Bu Young; Surh, Young-Joon Biochemical and Biophysical Research Communications, Vol.533 No.4, pp.995-1003	DOI
2021-01	STAT3 Stabilizes IKK alpha Protein through Direct Interaction in Transformed and Cancerous Human Breast Epithelial Cells Hahn, Young-Il; Saeidi, Soma; Kim, Su-Jung; Park, Se-Young; Song, Na-Young; Zheng, Jie; Kim, Do-Hee; Lee, Han-Byoel; Han, Wonshik; Noh, Dong-Young; Na, Hye-Kyung; Surh, Young-Joon Cancers, Vol.13 No.1, pp.1-15	DOI
2021-02	15-Deoxy-△12,14-Prostaglandin J2 Promotes Resolution of Experimentally Induced Colitis Kim, Wonki; Jang, Jeong-Hoon; Zhong, Xiancai; Seo, Hyungseok; Surh, Young-Joon Frontiers in Immunology, Vol.12	DOI
2021-03	Reprograming of Tumor-Associated Macrophages in Breast Tumor-Bearing Mice under Chemotherapy by Targeting Heme Oxygenase-1 Kim, Seung Hyeon; Kim, Su-Jung; Park, Jeongmin; Joe, Yeonsoo; Lee, So Eui; Saeidi, Soma; Zhong, Xiancai; Kim, Seong Hoon; Park, Sin-Aye; Na, Hye-Kyung; Chung, Hun Taeg; Surh, Young-Joon Antioxidants, Vol.10 No.3, pp.1-14	DOI
2021-03	Heregulin-β1 Activates NF-E2-related Factor 2 and Induces Manganese Superoxide Dismutase Expression in Human Breast Cancer Cells via Protein Kinase B and Extracellular Signal-regulated Protein Kinase Signaling Pathways Park, Ji-Young; Saeidi, Soma; Kim, Eun-Hee; Kim, Do-Hee; Na, Hye-Kyung; Keum, Joo-Seob; Surh, Young-Joon 대한암예방학회지, Vol.26 No.1, pp.54-63	DOI
2021-03	Protective effects of taurine chloramine on experimentally induced colitis: Nfκb, stat3, and nrf2 as potential targets Kim, Seong Hoon; Yum, Hye-Won; Kim, Seung Hyeon; Kim, Wonki; Kim, Su-Jung; Kim, Chaekyun; Kim, Kyeojin; Suh, Young-Ger; Surh, Young-Joon Antioxidants, Vol.10 No.3, pp.479-12	DOI
2021-03	15-Deoxy-Δ12,14-prostaglandin J2 Upregulates VEGF Expression via NRF2 and Heme Oxygenase-1 in Human Breast Cancer Cells Kim, Eun-Hee; Kim, Su-Jung; Na, Hye-Kyung; Han, Wonshik; Kim, Nam-Jung; Suh, Young-Ger; Surh, Young-Joon Cells, Vol.10 No.3, pp.526-24	DOI
2021-03	Stabilization of C/EBP beta through direct interaction with STAT3 in H-Ras transformed human mammary epithelial cells Lee, Lil-Li; Kim, Su-Jung; Hahn, Young-Il; Jang, Jeong-Hoon; Saeidi, Soma; Surh, Young-Joon Biochemical and Biophysical Research Communications, Vol.546, pp.130-137	DOI
2021-03	15-Deoxy-Delta(12,14)-prostaglandin J(2) binds and inactivates STAT3 via covalent modification of cysteine 259 in H-Ras-transformed human breast epithelial cells Kim, Su-Jung; Cho, Nam-Chul; Han, Bitnara; Kim, Kyeojin; Hahn, Young-Il; Kim, Kwang Pyo; Suh, Young Ger; Choi, Bu Young; Na, Hye-Kyung; Surh, Young-Joon FEBS Letters, Vol.595 No.5, pp.604-622	DOI
2021-03	Interaction of Nrf2 with dimeric STAT3 induces IL-23 expression: Implications for breast cancer progression Kim, Su-Jung; Saeidi, Soma; Cho, Nam-Chul; Kim, Seung Hyeon; Lee, Han-Byoel; Han, Wonshik; Noh, Dong-Young; Surh, Young-Joon Cancer Letters, Vol.500, pp.147-160	DOI
2021-03	Alternative regulation of HIF-1α stability through Phosphorylation on Ser451 Han, Hyeong-jun; Saeidi, Soma; Kim, Su-Jung; Piao, Juan-Yu; Lim, Sooa; Guillen-Quispe, Yanymee N.; Choi, Bu Young; Surh, Young-Joon Biochemical and Biophysical Research Communications, Vol.545, pp.150-156	DOI
2021-05	Resolvin D1 suppresses inflammation-associated tumorigenesis in the colon by inhibiting IL-6-induced mitotic spindle abnormality Lee, Ha-Na; Choi, Yeon-Seo; Kim, Seong Hoon; Zhong, Xiancai; Kim, Wonki; Park, Joon Sung; Saeidi, Soma; Han, Byung Woo; Kim, Nayoung; Lee, Hye Seung; Choi, Yoon Jin; Baek, Jeong-Heum; Na, Hye-Kyung; Surh, Young-Joon FASEB Journal, Vol.35 No.5, p. e21432	DOI
2021-05	IL-1β induces expression of proinflammatory cytokines and migration of human colon cancer cells through upregulation of SIRT1 Jung, Jaekyung; Lee, Yeon-Hwa; Fang, Xizhu; Kim, Su-Jung; Kim, Seong Hoon; Kim, Do-Hee; Song, Na-Young; Na, Hye-Kyung; Baek, Jeong-Heum; Surh, Young-Joon Archives of Biochemistry and Biophysics, Vol.703, p. 108847	DOI
2021-06	Protective Effects of Silibinin on Helicobacter pylori-induced Gastritis: NF-kappa B and STAT3 as Potential Targets Cho, Kyunghwa; Lee, Hee Geum; Piao, Juan-Yu; Kim, Su-Jung; Na, Hye-Kyung; Surh, Young-Joon 대한암예방학회지, Vol.26 No.2, pp.118-127	DOI
2021-06	Topically Applied Taurine Chloramine Protects against UVB-Induced Oxidative Stress and Inflammation in Mouse Skin Kim, Seong Hoon; Yum, Hye-Won; Kim, Seung Hyeon; Kim, Su-Jung; Kim, Kyeojin; Kim, Chaekyun; Suh, Young-Ger; Surh, Young-Joon Antioxidants, Vol.10 No.6, p. 867	DOI
2021-06	Changes in Microbial Community Composition Related to Sex and Colon Cancer by Nrf2 Knockout Song, Chin-Hee; Kim, Nayoung; Nam, Ryoung Hee; Choi, Soo In; Yu, Jeong Eun; Nho, Heewon; Surh, Young-Joon Frontiers in cellular and infection microbiology, Vol.11	DOI
2021-07	The Enhanced Inhibitory Effect of Estrogen on PD-L1 Expression Following Nrf2 Deficiency in the AOM/DSS Model of Colitis-Associated Cancer Kang, Changhee; Song, Chin-Hee; Kim, Nayoung; Nam, Ryoung Hee; Choi, Soo In; Yu, Jeong Eun; Nho, Heewon; Choi, Jin A.; Kim, Jin Won; Na, Hee Young; Lee, Ha-Na; Surh, Young-Joon Frontiers in Oncology, Vol.11	DOI
2021-08	Role of chemopreventive phytochemicals in NRF2-mediated redox homeostasis in humans Chun, Kyung-Soo; Raut, Pawan Kumar; Kim, Do-Hee; Surh, Young-Joon Free Radical Biology and Medicine, Vol.172, pp.699-715	DOI

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